Rabbit Polyclonal HDAC2(Ab-394) Antibody

The HDAC2 (Ab-394) antibody is a widely used tool for investigating histone deacetylase 2 (HDAC2), a key enzyme in epigenetic regulation. HDAC2. a member of the class I HDAC family, catalyzes the removal of acetyl groups from lysine residues on histones, promoting chromatin condensation and transcriptional repression. It plays critical roles in cell cycle control, differentiation, and apoptosis, with dysregulation linked to cancers, neurodegenerative disorders, and metabolic diseases. The Ab-394 antibody specifically targets HDAC2. often recognizing an epitope within its C-terminal domain, and is validated for applications such as Western blotting (WB), chromatin immunoprecipitation (ChIP), and immunofluorescence (IF). It demonstrates high specificity for HDAC2. with minimal cross-reactivity against other HDAC isoforms (e.g., HDAC1 or HDAC3), and is compatible with samples from humans, mice, and rats. Researchers employ this antibody to study HDAC2's involvement in gene silencing, its interactions with transcriptional complexes, and its pathological roles in disease models. Its reliability in detecting both endogenous and overexpressed HDAC2 makes it valuable for exploring therapeutic strategies targeting HDAC activity, particularly in oncology and neurology research. Proper validation using HDAC2 knockout controls is recommended to ensure specificity in experimental settings.