Rabbit Polyclonal HistoneH3.1(Ab-10) Antibody

The Histone H3.1 (Ab-10) antibody is a monoclonal antibody specifically designed to recognize histone H3.1. a replication-dependent histone variant critical for chromatin assembly during DNA replication. Histone H3.1 is a core component of nucleosomes, playing essential roles in maintaining chromatin structure, regulating gene expression, and ensuring genome stability. Unlike the replication-independent variant H3.3. H3.1 is predominantly incorporated into chromatin during the S phase of the cell cycle and is associated with transcriptional repression in heterochromatic regions. The Ab-10 clone targets an unmodified or post-translationally modified epitope on H3.1. depending on its intended application, making it valuable for studying chromatin dynamics, epigenetic regulation, and cell cycle progression. This antibody is widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate histone modifications, DNA replication processes, and aberrant epigenetic changes in diseases like cancer. Its specificity for H3.1 over other H3 variants enables researchers to dissect distinct roles of histone isoforms in chromatin remodeling and gene silencing. Validation in multiple experimental models underscores its reliability in both basic and translational research.