关键信息
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基因名
KCNAB3
- 应用
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别名
AKR6A9 ; K; K(+) channel subunit beta-3; K+ channel beta 3 subunit; KCAB3_HUMAN; KCNA3.1B; KCNA3B ; KCNAB 3; Kcnab3; KV BETA 3; KV BETA3; Kv-beta-3; MGC116886
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43448
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表达区间
1-404aa
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氨基酸序列
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP HSKK
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分子量
43.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KCNAB3, a member of the potassium channel family, encodes the beta subunit of voltage-gated potassium channels, which play crucial roles in regulating neuronal excitability and muscle contraction. Studies have shown that the KCNAB3 protein modulates the function and kinetics of the alpha subunits, contributing to the diverse physiological processes mediated by potassium channels. Understanding the structure and function of KCNAB3 is vital, as dysregulation of potassium channels has been implicated in various diseases, including epilepsy, arrhythmias, and other channelopathies. Recent advancements in recombinant protein technology have facilitated the production and characterization of KCNAB3, allowing researchers to explore its interactions with alpha subunits and other cellular proteins. This research not only elucidates the molecular mechanisms underlying potassium channel function but also holds therapeutic potential in drug development for conditions associated with ion channel dysfunction. Overall, the investigation of KCNAB3 recombinant protein is essential for advancing our understanding of potassium channel physiology and pathology.
