Rabbit Polyclonal JAK1(Ab-1022) Antibody

The JAK1 (Ab-1022) antibody is a well-characterized monoclonal antibody designed to specifically recognize and bind to the Janus kinase 1 (JAK1) protein, a member of the JAK family of tyrosine kinases. JAK1 plays a critical role in mediating cytokine receptor signaling, particularly pathways involving interferons, interleukins, and other ligands that activate the JAK-STAT signaling cascade. Dysregulation of JAK1 is implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancers. The Ab-1022 antibody is commonly used in research applications such as Western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) to detect endogenous JAK1 expression levels and study its activation, localization, or interactions in cellular models. It is often validated using knockout or knockdown controls to confirm specificity, with a target molecular weight of approximately 130-140 kDa. Raised in rabbit, this antibody demonstrates reactivity across human, mouse, and rat samples, making it a versatile tool for comparative studies. Researchers utilize JAK1 (Ab-1022) to investigate mechanisms underlying immune responses, oncogenic signaling, and therapeutic targeting of JAK-STAT pathways in both basic and translational biomedical research.