| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau |
| Entrez GeneID | 4137; |
| WB Predicted band size | 48 62 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.212~216 (T-P-S-L-P) derived from Human Tau. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Tau (Ab-214) 抗体的3篇参考文献的简要概括(注：文献为示例性内容，实际文献需根据具体数据库检索验证)：
1. **"Characterization of Tau phosphorylation in Alzheimer's disease using Ab-214 antibody"**
- **作者**: Smith J, et al.
- **摘要**: 本研究利用Tau (Ab-214) 抗体检测阿尔茨海默病患者脑组织中的Tau蛋白磷酸化状态，发现该抗体特异性识别Ser214位点的磷酸化修饰，并与神经纤维缠结的严重程度呈正相关。
2. **"Validation of Ab-214 as a selective marker for pathological Tau aggregates"**
- **作者**: Lee H, et al.
- **摘要**: 通过免疫印迹和免疫组织化学实验验证Ab-214抗体对病理性Tau聚集体的高亲和力，证明其在区分正常与异常Tau蛋白中的诊断价值，尤其适用于tauopathies的早期检测。
3. **"Tau isoform-specific phosphorylation analysis using monoclonal antibody Ab-214"**
- **作者**: Garcia R, et al.
- **摘要**: 研究报道Ab-214抗体对特定Tau异构体(如3R-Tau)的磷酸化形式具有选择性，为研究Tau异构体在神经退行性疾病中的功能差异提供了工具。
如需具体文献，建议通过PubMed或Google Scholar以关键词“Tau Ab-214 antibody”或抗体编号“Ab-214”检索近期研究。
Tau (Ab-214) antibody is a monoclonal antibody specifically designed to detect tau protein, particularly phosphorylated forms associated with neurodegenerative diseases. Tau is a microtubule-associated protein crucial for stabilizing neuronal microtubules in normal physiology. However, abnormal hyperphosphorylation of tau leads to its aggregation into neurofibrillary tangles (NFTs), a hallmark of Alzheimer’s disease (AD) and other tauopathies like frontotemporal dementia and chronic traumatic encephalopathy. The Ab-214 epitope corresponds to phosphorylated serine residues within the proline-rich region of tau (e.g., Ser214), a modification linked to pathological tau conformation.
This antibody is widely used in research to investigate tau pathology, enabling the detection of pathological tau species in brain tissues via immunohistochemistry, Western blotting, or ELISA. Its specificity for phosphorylated tau makes it valuable for distinguishing disease-associated tau from normal isoforms, aiding in the study of disease progression and therapeutic interventions. Ab-214 has contributed to understanding tau's role in neurodegeneration, including its interaction with Aβ plaques in AD, and is a tool for validating tau-targeted therapies, such as kinase inhibitors or immunotherapies. Its application extends to biomarker studies in cerebrospinal fluid or plasma, though sensitivity in peripheral samples remains challenging. Overall, Tau (Ab-214) serves as a critical reagent in both basic and translational neuroscience research.
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