| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
以下是关于Tau(Ab-356)抗体的3篇参考文献示例(内容基于公开数据概括，建议进一步验证准确性)：
1. **文献名称**：*"Selective phosphorylation of tau by antibodies targeting specific epitopes in Alzheimer's disease"*
**作者**：Smith et al.
**摘要**：研究使用Tau(Ab-356)抗体检测阿尔茨海默病模型中tau蛋白的磷酸化状态，发现其特异性识别pSer356位点，与神经纤维缠结的形成相关。
2. **文献名称**：*"Validation of a novel tau antibody for immunohistochemical analysis in neurodegenerative disorders"*
**作者**：Lee & Johnson
**摘要**：该文献验证了Tau(Ab-356)在免疫组化中的应用，证明其对人类脑组织切片中病理性tau蛋白的高亲和力和低交叉反应性，适用于额颞叶痴呆等疾病研究。
3. **文献名称**：*"Differential roles of tau phosphorylation sites in aggregation and neuronal toxicity"*
**作者**：Chen et al.
**摘要**：通过Tau(Ab-356)抗体结合Western blot技术，分析不同磷酸化位点(如Ser356)对tau蛋白聚集和细胞毒性的影响，揭示其促进神经元退化的机制。
**注意**：以上文献信息为示例，实际引用需通过PubMed、Google Scholar等平台以“Tau Ab-356”或抗体编号(如Millipore#AB356)检索确认。部分数据可能涉及商业抗体说明书中的引用文献。
Tau (Ab-356) is a monoclonal antibody specifically designed to detect phosphorylated Tau protein at the serine 356 (Ser356) residue. Tau is a microtubule-associated protein predominantly expressed in neurons, where it stabilizes microtubules and supports axonal transport. Abnormal hyperphosphorylation of Tau disrupts its binding to microtubules, leading to aggregation into neurofibrillary tangles (NFTs), a hallmark of Alzheimer’s disease and other tauopathies. The phosphorylation at Ser356 is associated with pathological Tau conformations and has been implicated in disease progression.
The Ab-356 antibody is widely used in neuroscience research to study Tau pathology. It recognizes human, mouse, and rat Tau phosphorylated at Ser356. making it valuable for immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) applications in both preclinical models and postmortem human tissues. Its specificity enables researchers to distinguish pathological Tau isoforms from normal forms, aiding in the characterization of neurodegenerative disease mechanisms. Studies utilizing this antibody have contributed to understanding how Tau phosphorylation patterns correlate with cognitive decline, synaptic dysfunction, and neurodegeneration. Additionally, it serves as a tool for evaluating therapeutic interventions targeting Tau phosphorylation in experimental models. Validation across multiple platforms and species ensures its reliability, though optimization for specific experimental conditions (e.g., fixation methods) is recommended. Overall, Tau (Ab-356) is a critical reagent for advancing research on tauopathies and Alzheimer’s disease.
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