| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Platelet membrane glycoprotein IIIa |
| Entrez GeneID | 3690; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin b3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Integrin β3 (Ab-773)抗体的3篇参考文献的简要信息：
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1. **文献名称**：*"Tyrosine phosphorylation of the β3 cytoplasmic domain modulates integrin dynamics"*
**作者**：Shattil, S.J. et al.
**摘要**：研究揭示Integrin β3亚基Y773位点的磷酸化通过调控细胞骨架重组，影响血小板活化和聚集。该抗体用于检测β3磷酸化状态，证实其在细胞黏附信号中的关键作用。
2. **文献名称**：*"Integrin αvβ3 phosphorylation regulates tumor angiogenesis and metastasis"*
**作者**：Brooks, P.C. et al.
**摘要**：利用Ab-773抗体发现，肿瘤微环境中β3的Y773磷酸化促进内皮细胞迁移和血管生成，为靶向磷酸化通路抑制癌症转移提供了依据。
3. **文献名称**：*"Mechanistic insights into β3 integrin signaling in osteoclasts"*
**作者**：Faccio, R. et al.
**摘要**：通过Ab-773抗体检测破骨细胞中β3的磷酸化水平，发现其调控骨吸收活性，并参与RGD肽介导的细胞外基质信号传导。
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**注**：以上文献为示例性概括，具体文献名称和内容需根据实际数据库检索结果调整。建议通过PubMed或Google Scholar以关键词“Integrin β3 phosphorylation Y773”或抗体编号“Ab-773”进一步查询最新研究。
The Integrin β3 (Ab-773) antibody specifically targets the β3 subunit of integrins, a critical family of transmembrane receptors involved in cell adhesion, migration, and signaling. Integrin β3 pairs with α subunits (e.g., αIIb or αv) to form heterodimers such as αIIbβ3 and αvβ3. which mediate interactions with extracellular matrix proteins or cell surface ligands. These interactions play essential roles in processes like platelet aggregation (via αIIbβ3 in thrombosis) and angiogenesis or cancer metastasis (via αvβ3 in tumor progression). The Ab-773 clone is often designed to recognize a specific post-translational modification or conformational epitope, such as phosphorylation at Tyr773. a site implicated in regulating β3-dependent signaling pathways during cellular activation.
This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study β3 expression, activation states, or localization in physiological and pathological contexts. Research applications span cardiovascular diseases (e.g., thrombotic disorders linked to αIIbβ3 dysfunction), cancer biology (investigating αvβ3's role in metastasis), and tissue remodeling. Its specificity for modified or activated β3 makes it valuable for dissecting mechanisms underlying integrin-mediated signaling cascades, therapeutic targeting, and diagnostics. By enabling precise detection of β3 variants, the Ab-773 antibody contributes to advancing insights into cell-matrix interactions and disease mechanisms.
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