| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R; |
| Entrez GeneID | 3480; |
| WB Predicted band size | 200 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R . |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGF-1R (Ab-1161)抗体的模拟参考文献示例(仅供参考，具体文献需通过学术数据库检索)：
1. **"IGF-1R signaling promotes tumor progression in triple-negative breast cancer"**
*Authors: Smith A, et al. (2020)*
摘要：研究利用IGF-1R (Ab-1161)抗体通过免疫组化和Western blot分析三阴性乳腺癌细胞系及临床样本，发现IGF-1R高表达与肿瘤侵袭性正相关，抑制其活性可降低癌细胞迁移能力。
2. **"Targeting IGF-1R in non-small cell lung cancer: A therapeutic strategy"**
*Authors: Chen L, et al. (2018)*
摘要：通过IGF-1R (Ab-1161)抗体检测肺癌组织中受体表达水平，结合体外实验证明靶向IGF-1R可增强化疗敏感性，并抑制PI3K/AKT通路激活，为联合治疗提供依据。
3. **"Role of IGF-1R in pancreatic beta-cell survival under metabolic stress"**
*Authors: Gupta R, et al. (2019)*
摘要：使用IGF-1R (Ab-1161)进行免疫沉淀和Western blot，揭示IGF-1R信号在糖尿病模型中保护β细胞免受氧化应激损伤的机制，提示其作为代谢疾病治疗靶点。
4. **"IGF-1R expression correlates with poor prognosis in osteosarcoma"**
*Authors: Martinez D, et al. (2021)*
摘要：基于IGF-1R (Ab-1161)抗体的免疫组化分析骨肉瘤组织微阵列，发现高表达患者总生存期较短，并验证IGF-1R抑制剂在动物模型中的抗肿瘤效果。
**注**：以上为模拟示例，实际文献需通过PubMed/Google Scholar以“IGF-1R Ab-1161”为关键词检索，或查阅抗体供应商(如CST)官网的产品引用列表。
The insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase receptor critical for regulating cell growth, differentiation, and survival by mediating signaling pathways such as PI3K/AKT and MAPK/ERK. Dysregulation of IGF-1R is implicated in cancer progression, metabolic disorders, and aging. The IGF-1R(Ab-1161) antibody is a well-characterized monoclonal antibody raised against a specific epitope within the C-terminal region of human IGF-1R. It is widely used in research to detect IGF-1R expression and activation in techniques like Western blotting, immunoprecipitation, and immunohistochemistry.
This antibody specifically recognizes the full-length IGF-1R protein (∼130 kDa α-subunit and ∼95 kDa β-subunit) and does not cross-react with the closely related insulin receptor (IR), ensuring high specificity in experimental settings. Researchers employ IGF-1R(Ab-1161) to study receptor overexpression in cancers (e.g., breast, lung) or its role in metabolic signaling. It is also used to evaluate therapeutic agents targeting IGF-1R, such as tyrosine kinase inhibitors or monoclonal antibodies in preclinical models. Validation across multiple species (human, mouse, rat) enhances its utility in translational studies. Proper controls, including knockdown or knockout samples, are recommended to confirm signal specificity due to potential post-translational modifications or isoform variations.
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