Rabbit Polyclonal VEGFR2(Ab-951) Antibody

VEGFR2 (Ab-951) is an antibody specifically targeting the vascular endothelial growth factor receptor 2 (VEGFR2), a critical tyrosine kinase receptor also known as KDR (kinase insert domain receptor) or Flk-1 (fetal liver kinase-1). VEGFR2 is primarily expressed on endothelial cells and plays a central role in regulating angiogenesis and lymphangiogenesis by mediating cellular responses to VEGF-A, VEGF-C, and VEGF-D. Activation of VEGFR2 triggers downstream signaling pathways, including MAPK/ERK and PI3K/Akt, which promote cell proliferation, migration, and survival. The Ab-951 epitope corresponds to a phosphorylated tyrosine residue (Tyr951) within the kinase domain of VEGFR2. a key site for receptor autophosphorylation and signal transduction. This antibody is widely used in research to investigate VEGFR2 activation status, particularly in studies related to tumor angiogenesis, metastatic progression, and anti-angiogenic therapy resistance. It has applications in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. As dysregulated VEGFR2 signaling is implicated in cancers, inflammatory diseases, and ocular disorders, the Ab-951 antibody serves as a valuable tool for both mechanistic studies and preclinical evaluation of targeted therapies, including tyrosine kinase inhibitors and monoclonal antibodies aimed at blocking VEGF-driven pathways.