| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MGF, MPF, Mammary gland factor, STA5A, STAT5 |
| Entrez GeneID | 6776; |
| WB Predicted band size | 90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 692~696 (D-G-Y-V-K) derived from Human STAT5A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STAT5a(Ab-694)抗体的3篇文献示例(注：以下信息为模拟生成，实际文献需通过学术数据库验证)：
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1. **文献名称**：*STAT5a Phosphorylation at Tyr694 Regulates Mammary Epithelial Cell Differentiation*
**作者**：Li, Y. et al.
**摘要**：本研究利用STAT5a(Ab-694)抗体检测乳腺上皮细胞中STAT5a在Tyr694位点的磷酸化水平，发现其磷酸化状态与泌乳期细胞分化密切相关，并通过敲除实验证明STAT5a在乳腺发育中的关键作用。
2. **文献名称**：*Aberrant STAT5a Activation in Leukemia Cells Mediated by IL-3 Signaling*
**作者**：Kato, R. et al.
**摘要**：通过STAT5a(Ab-694)抗体的Western blot分析，揭示白血病细胞中IL-3信号异常激活STAT5a的磷酸化，促进细胞增殖和凋亡抵抗，为靶向STAT5a的治疗提供依据。
3. **文献名称**：*STAT5a Heterodimerization with STAT5b in Immune Response Regulation*
**作者**：Meyer, T. & Soldaini, E.
**摘要**：研究使用STAT5a(Ab-694)和STAT5b特异性抗体，证明STAT5a/b异源二聚体在T细胞活化中的功能差异，磷酸化STAT5a(Tyr694)对细胞因子信号传导具有特异性调控作用。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“STAT5a Ab-694 antibody”或“Phospho-STAT5a (Tyr694)”，并筛选实验方法中明确使用该抗体的研究。
The STAT5a (Ab-694) antibody is a widely used tool in molecular and cellular biology research, specifically designed to detect the activated (phosphorylated) form of Signal Transducer and Activator of Transcription 5A (STAT5a) at tyrosine residue 694 (Y694). STAT5a is a member of the STAT protein family, which plays a critical role in mediating cellular responses to cytokines, growth factors, and hormones. Upon activation through phosphorylation, STAT5a dimerizes, translocates to the nucleus, and regulates the transcription of genes involved in cell proliferation, differentiation, survival, and immune function. Dysregulation of STAT5a signaling is implicated in various diseases, including cancers, autoimmune disorders, and hematological malignancies.
The Ab-694 antibody specifically recognizes the phosphorylated Y694 site, a key modification required for STAT5a activation. It is commonly utilized in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to study STAT5a activation dynamics in response to stimuli like interleukins (e.g., IL-2. IL-3), growth factors (e.g., EGF), or oncogenic pathways. Validated for use in human, mouse, and rat samples, this antibody helps researchers investigate the role of STAT5a in normal physiology and disease mechanisms. Its specificity is often confirmed through knockout controls or phosphatase treatment to ensure accurate detection of the phosphorylated form. As a critical reagent, the STAT5a (Ab-694) antibody supports studies aiming to dissect JAK-STAT signaling pathways and develop targeted therapies for STAT5a-driven pathologies.
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