关键信息
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基因名
DEFB1
- 应用
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别名
DEFB1；BD1；HBD1；Beta-defensin 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P60022
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表达区间
22-68aa
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氨基酸序列
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
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分子量
5.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Defensin beta 1 (DEFB1), a member of the defensin family, is an antimicrobial peptide that plays a crucial role in the innate immune response. It is predominantly expressed by epithelial cells in various tissues, including the respiratory and gastrointestinal tracts. DEFB1 exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi, making it vital for the host's first line of defense against infections. The study of DEFB1 has gained significant interest due to its potential therapeutic applications in treating infections and inflammatory diseases. Research has highlighted its role in modulating immune responses and promoting wound healing, while alterations in its expression levels have been associated with various health conditions, including inflammatory bowel disease and respiratory infections. Recombinant DEFB1 protein is increasingly being produced for both functional studies and potential therapeutic use, enabling a better understanding of its mechanisms of action and interactions within the immune system. Consequently, ongoing studies aim to optimize its production and explore its applications in developing novel antimicrobial agents and adjuvants for vaccines, underscoring the importance of this peptide in both innate immunity and clinical therapeutics.
