| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AP-1 |
| Entrez GeneID | 3726; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.77~81 (G-A-S-L-K) derived from Human JunB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JunB (Ab-79)抗体的示例参考文献(仅供参考，建议通过数据库验证具体信息)：
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1. **"AP-1 transcription factors in epidermal differentiation and skin cancer"**
- **作者**: Zenz, R. et al.
- **摘要**: 研究JunB(通过Ab-79抗体检测)与AP-1家族成员在表皮分化和皮肤疾病(如银屑病)中的作用，发现JunB缺失导致炎症和增生异常。
2. **"JunB regulates homeostasis and effector functions of T helper cells"**
- **作者**: Li, B. et al.
- **摘要**: 使用JunB (Ab-79)抗体进行ChIP-seq和免疫印迹，揭示JunB在Th细胞分化和免疫应答中的关键调控机制。
3. **"The role of JunB in tumor angiogenesis and progression"**
- **作者**: Passegué, E. & Wagner, E.F.
- **摘要**: 通过免疫组化(Ab-79抗体)分析JunB在肿瘤微环境中的表达，发现其通过调控VEGF促进血管生成和癌症转移。
4. **"Cyclin D1 expression is controlled by JunB in cellular senescence"**
- **作者**: Wisdom, R. & Verma, I.M.
- **摘要**: 研究JunB(使用Ab-79抗体)与细胞周期蛋白Cyclin D1的调控关系，揭示其在细胞衰老和肿瘤抑制中的功能。
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**注**：上述文献为示例，实际引用需根据抗体供应商(如Santa Cruz, Cat# sc-8051)的产品说明书或PubMed等平台检索具体研究。建议通过抗体编号或作者名在文献数据库(如Google Scholar)中确认相关论文。
JunB is a member of the AP-1 (Activator Protein-1) family of transcription factors, which regulate gene expression in response to cellular signals such as stress, cytokines, and growth factors. As a dimeric protein, JunB partners with other AP-1 components (e.g., Fos, Jun, or ATF proteins) to bind DNA and modulate transcriptional activity. It plays critical roles in cell proliferation, differentiation, apoptosis, and immune responses, with context-dependent pro-oncogenic or tumor-suppressive functions. Dysregulation of JunB is implicated in cancers, inflammatory diseases, and developmental disorders.
The JunB (Ab-79) antibody is a monoclonal antibody developed to specifically recognize the JunB protein. It typically targets an epitope within the N-terminal region of human JunB, enabling detection in applications like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Validated for use in human, mouse, and rat samples, this antibody aids in studying JunB's expression patterns, subcellular localization, and interactions in physiological and pathological contexts. Its utility extends to research on cancer biology (e.g., breast cancer, leukemia), immune regulation (e.g., T-cell differentiation), and tissue homeostasis (e.g., skin development). As JunB's activity is tightly regulated by post-translational modifications and cellular signaling pathways, this antibody serves as a key tool for dissecting its complex roles in health and disease.
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