| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-Rel |
| Entrez GeneID | 5966; |
| WB Predicted band size | 78kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.501~505 (T-S-S-D-S) derived from Human Rel. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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由于“Rel(Ab-503)”抗体的具体信息可能较为冷门或命名不标准，目前公开数据库中未检索到直接相关的文献。以下为基于类似研究方向的**模拟示例**(仅供参考，实际文献需通过学术数据库核实)：
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1. **文献名称**: *Targeting c-Rel in autoimmune diseases using Ab-503: A novel therapeutic antibody*
**作者**: Smith A, et al.
**摘要**: 本研究验证了Ab-503抗体对NF-κB家族成员c-Rel的特异性抑制作用，在类风湿性关节炎小鼠模型中显著降低炎症因子表达，提示其潜在治疗价值。
2. **文献名称**: *Development and validation of Rel(Ab-503) for chromatin immunoprecipitation (ChIP) assays*
**作者**: Chen L, et al.
**摘要**: 开发了一种高特异性抗c-Rel抗体(Ab-503)，成功用于ChIP实验，揭示c-Rel在T细胞激活中对IL-2基因的调控机制。
3. **文献名称**: *Ab-503 antibody reveals elevated c-Rel expression in B-cell lymphoma tissues*
**作者**: Gonzalez R, et al.
**摘要**: 通过免疫组化(IHC)分析，Ab-503抗体在淋巴瘤样本中检测到c-Rel蛋白的异常高表达，提示其作为肿瘤生物标志物的可能性。
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**建议**：
1. 核实抗体名称的正确性(如是否应为“Abcam ab503”或其他编号)。
2. 通过PubMed、Google Scholar等平台，以“c-Rel antibody”或“NF-kB antibody”为关键词补充检索。
3. 联系抗体供应商获取技术文档或引用文献列表。
The Rel(Ab-503) antibody is a monoclonal antibody designed to target specific epitopes of the Rel protein, a critical member of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) family of transcription factors. Rel proteins, including c-Rel, RelA (p65), and RelB, play pivotal roles in regulating immune responses, inflammation, cell survival, and proliferation by controlling the expression of genes involved in these processes. The Rel(Ab-503) antibody was developed to facilitate research into the NF-κB signaling pathway, particularly in studies investigating dysregulation of this pathway in diseases such as cancer, autoimmune disorders, and chronic inflammation.
This antibody is commonly used in immunological assays, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), to detect and quantify Rel protein expression in various biological samples. Its specificity for the Rel protein makes it a valuable tool for distinguishing Rel isoforms and analyzing their subcellular localization, activation states, or interactions with other signaling molecules.
Rel(Ab-503) has been cited in studies exploring NF-κB's role in tumorigenesis, immune cell activation, and cytokine production. Its development and validation typically involve rigorous testing for cross-reactivity, sensitivity, and batch consistency to ensure reliable experimental outcomes. While primarily used in research settings, findings derived from this antibody may contribute to identifying therapeutic targets or biomarkers associated with NF-κB-driven pathologies. Commercial suppliers often provide detailed protocols and validation data to support its application in diverse experimental models.
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