| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TAB1, 3'-Tab1, 3-Tab1, MAP3K7IP1, TAK1-binding protein 1 |
| Entrez GeneID | 10454; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human TAB1 (Phospho-Ser438) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 30% glycerol. |
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以下是关于TAB1 (Phospho-Ser438)抗体的参考文献示例(内容基于模拟数据，实际文献需通过学术数据库验证)：
1. **文献名称**：*TAK1 Activation Requires TAB1 Phosphorylation at Ser-438*
**作者**：Smith A, et al.
**摘要**：研究揭示了TAB1在Ser-438位点的磷酸化对TAK1激酶活化的必要性，通过Phospho-Ser438抗体验证了其在炎症信号通路中的关键作用。
2. **文献名称**：*Role of TAB1 Phosphorylation in Cardiac Hypertrophy*
**作者**：Chen L, et al.
**摘要**：利用Phospho-Ser438特异性抗体，发现TAB1在压力超负荷心脏模型中发生磷酸化，并促进病理性心肌肥厚。
3. **文献名称**：*Development of a Phospho-Specific Antibody Targeting TAB1 Ser-438*
**作者**：Johnson R, et al.
**摘要**：描述了该抗体的制备与验证，证明其可特异性识别TAB1磷酸化形式，并应用于检测细胞应激条件下的修饰水平。
4. **文献名称**：*TAB1 Autophosphorylation at Ser-438 Modulates TLR4 Signaling*
**作者**：Wang Y, et al.
**摘要**：通过Phospho-Ser438抗体证实，TAB1自身磷酸化调控TLR4介导的NF-κB激活，影响先天免疫反应。
建议通过**PubMed**或**Google Scholar**搜索具体文献，结合关键词“TAB1 Ser438 phosphorylation”或抗体货号(如商业化抗体)获取全文。
The TAB1 (Phospho-Ser438) antibody is a specialized tool used to detect the phosphorylation of Transforming Growth Factor-beta (TGF-β)-Activated Kinase 1 (TAK1)-Binding Protein 1 (TAB1) at serine residue 438. TAB1 is a critical adaptor protein that interacts with TAK1. a kinase involved in multiple signaling pathways, including NF-κB and MAPK cascades, which regulate inflammation, immune responses, and apoptosis. Phosphorylation of TAB1 at Ser438 is a key post-translational modification that modulates TAK1 activation. This autophosphorylation event is thought to stabilize the TAK1-TAB1 complex, enhancing downstream signaling in response to stimuli such as cytokines, stress, or microbial components.
The TAB1 (Phospho-Ser438) antibody enables researchers to study the activation status and regulatory mechanisms of the TAK1 pathway in various contexts, including cancer, autoimmune diseases, and infection. It is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess phosphorylation-dependent interactions or pathway activity. Dysregulation of TAK1-TAB1 signaling has been linked to pathological conditions, making this antibody valuable for investigating disease mechanisms or therapeutic targets. Its specificity for the phosphorylated form of TAB1 helps distinguish active versus inactive signaling states, providing insights into cellular responses to extracellular cues.
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