Rabbit Polyclonal Kizuna(Phospho-Thr379) Antibody

The Kizuna (Phospho-Thr379) antibody is a specialized tool used to detect the phosphorylated form of the Kizuna protein (also known as KIAA1409 or SPD-2) at threonine residue 379. Kizuna is a microtubule-associated protein critical for maintaining spindle stability during mitosis, particularly in ensuring proper chromosome segregation and cytokinesis. Phosphorylation at Thr379 is a key post-translational modification linked to its functional regulation during cell division. This modification is believed to modulate Kizuna's interaction with other spindle-associated proteins or its ability to stabilize microtubule networks. The antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study Kizuna's activation dynamics, especially in contexts such as mitotic progression, DNA damage response, or cancer research where spindle defects contribute to genomic instability. Researchers often validate its specificity using knockout cell lines or phosphatase-treated lysates. Understanding Kizuna's phosphorylation status provides insights into cell cycle regulation, mitotic errors, and potential therapeutic targets for diseases like cancer. The antibody's development reflects the growing interest in post-translational modifications as biomarkers for cellular processes and disease mechanisms.