Rabbit Polyclonal EPHA8(Phospho-Tyr838) Antibody

The EPHA8 (Phospho-Tyr838) antibody is a specialized tool used to detect the phosphorylation of tyrosine residue 838 (Y838) in the Ephrin type-A receptor 8 (EPHA8), a member of the Eph receptor tyrosine kinase family. EPHA8 plays critical roles in cell-cell communication, tissue patterning, and developmental processes, particularly in the nervous system. Its activation relies on binding to ephrin ligands, triggering bidirectional signaling that regulates cell adhesion, migration, and cytoskeletal dynamics. Phosphorylation at Y838 is a key post-translational modification associated with receptor activation, influencing downstream signaling cascades. This antibody is commonly employed in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study EPHA8 activation status in physiological or pathological contexts, such as cancer, neurodevelopment, or tissue repair. Researchers use it to explore how EPHA8 phosphorylation modulates cellular responses in diseases, including tumor progression or neurological disorders. Specificity validation (e.g., knockout controls) is essential to ensure accurate detection, as cross-reactivity with other Eph receptors or non-phosphorylated EPHA8 could lead to misinterpretation. Understanding EPHA8 signaling via this antibody aids in unraveling its therapeutic potential as a target for precision medicine.