Rabbit Polyclonal Tensin-1(Phospho-Tyr1326) Antibody

The Tensin-1 (Phospho-Tyr1326) antibody is designed to detect the phosphorylated form of Tensin-1 at tyrosine residue 1326. a post-translational modification critical for its functional regulation. Tensin-1 is a focal adhesion protein that links the actin cytoskeleton to integrin-mediated cell-matrix adhesion sites, playing key roles in cell migration, proliferation, and mechanical signaling. Phosphorylation at Tyr1326. often mediated by Src family kinases or focal adhesion kinase (FAK), modulates Tensin-1’s interactions with signaling molecules and structural proteins, influencing cytoskeletal dynamics and adhesion complex turnover. This antibody is widely used in studies exploring cellular responses to extracellular cues, such as wound healing, cancer metastasis, or mechanotransduction. Researchers employ it in techniques like Western blotting, immunofluorescence, or immunohistochemistry to assess Tensin-1 activation status in cell lines, tissues, or disease models. Its specificity for the phosphorylated epitope helps dissect signaling pathways involving integrin-mediated adhesion and tyrosine kinase cascades. Dysregulation of Tensin-1 phosphorylation has been implicated in pathological conditions, including tumor invasion and fibrosis, making this antibody a valuable tool for both basic research and translational studies targeting adhesion-related disorders.