| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD antigen CD71 |
| Entrez GeneID | 7037; |
| WB Predicted band size | 89kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human CD71 around the phosphorylation site of S24. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD71 (Phospho-Ser24)抗体的3篇参考文献，按文献名称、作者和摘要内容整理：
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1. **文献名称**: *"Phosphorylation of Transferrin Receptor at Serine 24 Regulates Endocytosis and Iron Homeostasis"*
**作者**: Smith A, et al.
**摘要**: 研究揭示了CD71(转铁蛋白受体)在Ser24位点的磷酸化通过调控其内吞作用影响细胞铁吸收的机制，并证实该抗体可用于检测细胞周期依赖的磷酸化修饰。
2. **文献名称**: *"CD71 Serine 24 Phosphorylation as a Marker of Proliferating Cells in Solid Tumors"*
**作者**: Chen L, et al.
**摘要**: 利用CD71 (Phospho-Ser24)抗体验证了该磷酸化位点在多种癌症中与细胞增殖相关，可能作为肿瘤生长的新型生物标志物。
3. **文献名称**: *"Kinase-Specific Regulation of Transferrin Receptor Trafficking by Phosphorylation of Serine 24"*
**作者**: Johnson R, et al.
**摘要**: 通过体外实验证明，Ser24磷酸化由AMPK激酶介导，影响CD71的膜定位及功能，该抗体被用于免疫印迹和免疫荧光检测。
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注：以上文献信息为模拟示例，实际文献需通过PubMed或Google Scholar等平台检索确认。
The CD71 (Phospho-Ser24) antibody is a specialized tool used to detect the phosphorylated form of CD71 (Transferrin Receptor 1. TfR1) at serine residue 24. CD71 is a transmembrane glycoprotein critical for cellular iron uptake by binding transferrin-iron complexes, a process tightly linked to cell proliferation, particularly in rapidly dividing cells like cancer cells. Phosphorylation at Ser24 is associated with post-translational regulation of CD71. potentially influencing receptor internalization, recycling, or interaction with signaling pathways. This modification may serve as a biomarker for cellular iron demand or proliferative states.
The antibody is widely utilized in research to study iron metabolism, cell cycle progression, and diseases such as cancer, anemia, and neurodegenerative disorders. It enables specific detection of phosphorylated CD71 via techniques like Western blotting, immunofluorescence, or immunoprecipitation, helping to dissect mechanisms underlying iron-dependent pathways or therapeutic targeting. In oncology, CD71 phosphorylation status may correlate with tumor aggressiveness, making this antibody valuable for exploring targeted therapies. Its specificity for the Ser24-phosphorylated epitope ensures minimal cross-reactivity with non-phosphorylated CD71 or other phosphoproteins, enhancing experimental accuracy. Overall, this antibody provides insights into the dynamic regulation of iron homeostasis and its intersection with cellular growth and disease pathology.
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