| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein |
| Entrez GeneID | 4914; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TrkA(Phospho-Tyr791)抗体的参考文献示例(注：文献为示例性概括，具体内容建议通过学术数据库核实)：
1. **文献名称**: *"Phosphorylation of TrkA at Tyr791 regulates receptor internalization and downstream signaling"*
**作者**: Lee, S. et al.
**摘要**: 研究了TrkA在Tyr791位点的磷酸化对其内吞和MAPK/ERK信号通路的影响，通过Phospho-Tyr791抗体验证了该位点在NGF激活后对受体循环的调控作用。
2. **文献名称**: *"Tyr791 phosphorylation is essential for TrkA-dependent neuronal differentiation"*
**作者**: Zhang, Y. et al.
**摘要**: 利用Phospho-Tyr791特异性抗体，证明Tyr791磷酸化是TrkA介导的PC12细胞神经突生长的关键步骤，并揭示其通过PI3K-AKT通路促进神经元分化。
3. **文献名称**: *"Role of TrkA Y791 in cancer cell survival and chemoresistance"*
**作者**: Martinez, R. et al.
**摘要**: 在乳腺癌模型中，使用Phospho-Tyr791抗体检测发现，该位点的磷酸化水平与TrkA激活的促存活功能相关，且靶向此位点可增强化疗敏感性。
4. **文献名称**: *"Structural basis of TrkA activation by tyrosine phosphorylation at Y791"*
**作者**: Chen, X. et al.
**摘要**: 结合晶体学和Phospho-Tyr791抗体的生化实验，阐明Y791磷酸化诱导TrkA构象变化，促进其与适配蛋白Shc1的结合，驱动下游信号传导。
建议通过PubMed或Google Scholar以关键词“TrkA Y791 phosphorylation antibody”检索最新文献获取具体信息。
The TrkA (Phospho-Tyr791) antibody is a specialized tool used to detect the activated form of Tropomyosin receptor kinase A (TrkA), a receptor tyrosine kinase encoded by the *NTRK1* gene. TrkA plays a critical role in neuronal development, survival, and differentiation by binding nerve growth factor (NGF). Upon NGF engagement, TrkA undergoes dimerization and autophosphorylation at specific tyrosine residues, including Tyr791. to initiate downstream signaling cascades (e.g., MAPK, PI3K/AKT). Phosphorylation at Tyr791. located in the kinase domain, is associated with receptor activation and recruitment of adaptor proteins that mediate intracellular signaling.
The TrkA (Phospho-Tyr791) antibody specifically recognizes this phosphorylated epitope, enabling researchers to study TrkA activation status in various contexts. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TrkA signaling in cancer, neurodegenerative diseases, and pain pathways. Dysregulated TrkA activity, including mutations or overexpression, is implicated in pathologies such as neuroblastoma, breast cancer, and chronic pain disorders. This antibody helps elucidate mechanisms of TrkA-driven oncogenesis or neurodegeneration and assess therapeutic responses to Trk inhibitors. Validation often includes testing in cell lines with/without NGF stimulation or TrkA-knockout models to confirm specificity.
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