Rabbit Polyclonal p90RSK(Phospho-Thr348) Antibody

The p90RSK (Phospho-Thr348) antibody is a specific tool used to study the activated form of p90 ribosomal S6 kinase (RSK), a serine/threonine kinase belonging to the RSK family. RSK proteins are downstream effectors of the ERK/MAPK signaling pathway and play critical roles in regulating cell survival, proliferation, and transcription. Phosphorylation at Thr348. located within the C-terminal kinase domain of p90RSK, is a key regulatory event required for full kinase activation. This phosphorylation is mediated by ERK1/2. which binds to and phosphorylates RSK in response to extracellular stimuli such as growth factors, hormones, or stress signals. The p90RSK (Phospho-Thr348) antibody selectively detects RSK isoforms (RSK1-3) when phosphorylated at this residue, enabling researchers to assess RSK activation status in various biological contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate RSK signaling dynamics in cell lines, tissues, or disease models. Studies utilizing this antibody have contributed to understanding RSK's role in cancer progression, metabolic regulation, and neuronal survival. Its specificity is often validated through peptide competition assays or phosphatase treatment controls. Dysregulation of RSK activity, detectable via Thr348 phosphorylation, has been implicated in tumorigenesis, neurodegenerative disorders, and metabolic syndromes, making this antibody a valuable tool in both basic research and translational studies.