| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1 |
| Entrez GeneID | 5701 |
| WB Predicted band size | 48.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This antibody is generated from a mouse immunized with a recombinant protein from human. |
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以下是关于PSMC2抗体的假设参考文献示例(仅供参考，非真实文献)：
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1. **文献名称**：*"PSMC2 Overexpression Promotes Tumorigenesis in Triple-Negative Breast Cancer via Proteasome Dysregulation"*
**作者**：Chen et al.
**摘要**：研究通过免疫组化和Western blot分析PSMC2在三阴性乳腺癌中的表达，发现其高表达导致蛋白酶体活性异常，促进肿瘤增殖和转移，提示PSMC2可能成为治疗靶点。
2. **文献名称**：*"Development and Validation of a High-Affinity Monoclonal Antibody for PSMC2 in Neurodegenerative Disease Models"*
**作者**：Tanaka et al.
**摘要**：本文报道了一种高特异性抗PSMC2单克隆抗体的开发，并在阿尔茨海默病小鼠模型中验证其应用，证实PSMC2表达下降与神经元蛋白酶体功能障碍相关。
3. **文献名称**：*"PSMC2 as a Biomarker for Chemoresistance in Colorectal Cancer: Insights from Antibody-Based Profiling"*
**作者**：Garcia-Ruiz et al.
**摘要**：利用PSMC2抗体分析结直肠癌患者的组织样本，发现化疗耐药患者的PSMC2表达显著上调，提示其可作为预测化疗反应的潜在标志物。
4. **文献名称**：*"Functional Characterization of PSMC2 in the 26S Proteasome Assembly Using CRISPR/Cas9 and Antibody-Mediated Knockdown"*
**作者**：Kim et al.
**摘要**：通过CRISPR/Cas9敲除和PSMC2抗体介导的蛋白抑制实验，揭示PSMC2在26S蛋白酶体组装中的关键作用及其对细胞周期调控的影响。
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**备注**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的论文。
The PSMC2 (Proteasome 26S Subunit, ATPase 2) antibody is a research tool targeting the PSMC2 protein, a critical component of the 26S proteasome. The 26S proteasome, a large multi-subunit complex, plays a central role in the ubiquitin-proteasome system (UPS), responsible for degrading ubiquitinated proteins to maintain cellular homeostasis. PSMC2. part of the 19S regulatory particle, contains ATPase activity essential for substrate unfolding, translocation into the proteolytic 20S core, and regulation of proteasome assembly.
PSMC2 antibodies are widely used to study proteasome dynamics, protein turnover mechanisms, and UPS-related pathologies. They enable detection of PSMC2 expression levels via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Dysregulation of PSMC2 is implicated in cancer, neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and autoimmune disorders, making its antibody valuable for investigating disease mechanisms. Additionally, PSMC2 antibodies aid in exploring cellular responses to proteasome inhibitors (e.g., bortezomib), which are therapeutic agents for multiple myeloma.
Research utilizing PSMC2 antibodies contributes to understanding proteasome function in cell cycle regulation, DNA repair, and stress responses. Their specificity and reliability are crucial for validating proteasome composition in diverse experimental models, from cell lines to clinical tissues.
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