| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fibroblast growth factor receptor 4, FGFR-4, Protein-tyrosine kinase receptor MPK-11, CD334, Fgfr4, Fgfr-4, Mpk-11 |
| Entrez GeneID | 14186 |
| WB Predicted band size | 88.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Fgfr4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 448-482 amino acids from the Central region of Mouse Fgfr4. |
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以下是关于Mouse Fgfr4抗体的参考文献示例(注：以下为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*Role of Fgfr4 in Liver Regeneration: Insights from Mouse Models*
**作者**：Smith A, et al.
**摘要**：本研究通过Western blot和免疫组化分析，利用特异性Mouse Fgfr4抗体，揭示了Fgfr4在小鼠肝脏再生中的关键作用。结果显示，Fgfr4缺失导致肝细胞增殖显著减少，表明其通过调控MAPK信号通路影响再生过程。
2. **文献名称**：*Fgfr4 Expression in Pancreatic Cancer Progression*
**作者**：Chen L, et al.
**摘要**：通过免疫荧光和流式细胞术结合Mouse Fgfr4抗体，研究发现Fgfr4在转基因小鼠胰腺癌模型中高表达，并与肿瘤侵袭性呈正相关。抑制Fgfr4后，癌细胞迁移能力显著降低。
3. **文献名称**：*Developmental Regulation of Fgfr4 in Mouse Embryonic Tissues*
**作者**：Wang Y, et al.
**摘要**：利用Fgfr4抗体进行胚胎组织染色，发现Fgfr4在小鼠心脏和骨骼肌发育中动态表达。基因敲除实验表明，Fgfr4缺失导致胚胎心脏形态异常，提示其在器官形成中的必要性。
4. **文献名称**：*Fgfr4 Modulates Glucose Metabolism in Diabetic Mouse Models*
**作者**：Kim H, et al.
**摘要**：研究通过Western blot和免疫沉淀技术，使用Fgfr4抗体证实了Fgfr4在糖尿病小鼠肝脏中的异常激活。阻断Fgfr4可改善胰岛素抵抗，提示其作为代谢疾病治疗靶点的潜力。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如“Mouse Fgfr4 antibody”、“Fgfr4 in vivo study”)，并筛选涉及抗体应用的实验研究。
Mouse FGFR4 (Fibroblast Growth Factor Receptor 4) is a transmembrane tyrosine kinase receptor belonging to the FGFR family, which regulates critical cellular processes like proliferation, differentiation, and survival. It binds to FGF ligands, activating downstream signaling pathways such as MAPK/ERK and PI3K/AKT. FGFR4 is particularly implicated in tissue development, metabolism, and disease progression, including roles in liver function, muscle regeneration, and cancer. Dysregulation of FGFR4 has been linked to hepatocellular carcinoma, rhabdomyosarcoma, and metabolic disorders, making it a target for therapeutic research.
Antibodies against mouse FGFR4 are essential tools for studying its expression, localization, and function in biological systems. These antibodies are typically developed using immunogenic peptides or recombinant proteins from the extracellular or intracellular domains of FGFR4. Validated applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. High specificity is crucial to avoid cross-reactivity with other FGFR family members (FGFR1-3). Researchers use these antibodies to explore FGFR4's role in developmental biology, tumorigenesis, and tissue repair models. Recent studies also focus on FGFR4's interaction with FGF19 in bile acid metabolism, highlighting its potential as a drug target. Quality assurance via knockout validation or blocking assays ensures reliability in experimental outcomes.
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