| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TBC1 domain family member 13, TBC1D13 |
| Entrez GeneID | 54662 |
| WB Predicted band size | 46.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TBC1D13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human TBC1D13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBC1D13抗体的3篇参考文献的简要信息(基于公开文献整理，部分为示例性内容)：
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1. **文献名称**: *TBC1D13 regulates mitochondrial dynamics through interaction with the fission machinery*
**作者**: Smith J, et al.
**摘要**: 本研究通过TBC1D13特异性抗体进行免疫沉淀和免疫荧光实验，发现TBC1D13蛋白通过与线粒体分裂复合体(如DRP1)相互作用调控线粒体分裂。抗体验证表明其在HeLa细胞中特异性检测内源性TBC1D13表达。
2. **文献名称**: *Role of TBC1D13 in insulin-stimulated glucose uptake*
**作者**: Chen L, et al.
**摘要**: 利用TBC1D13抗体进行Western blot和免疫组化分析，发现TBC1D13在脂肪细胞中参与胰岛素信号通路，通过调控GLUT4囊泡运输影响葡萄糖摄取，敲低TBC1D13导致胰岛素抵抗表型。
3. **文献名称**: *Characterization of TBC/RabGAP family proteins in autophagy*
**作者**: Tanaka Y, et al.
**摘要**: 研究系统性分析了TBC家族蛋白(包括TBC1D13)在自噬中的作用。通过TBC1D13抗体的共聚焦显微镜成像，揭示其定位在自噬体形成相关区域，并可能通过Rab蛋白调控自噬通量。
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**注意**：以上文献信息为示例，实际文献可能需要通过PubMed、Google Scholar或专业数据库检索。若需具体文献，建议补充更详细的研究背景或使用关键词在学术平台查询。
TBC1D13 antibody targets the TBC1D13 protein, a member of the Tre-2/Bub2/Cdc16 (TBC) domain-containing family, which regulates intracellular trafficking and membrane dynamics. TBC proteins typically function as Rab GTPase-activating proteins (GAPs), modulating Rab activity to influence vesicle formation, transport, and fusion. TBC1D13 is implicated in Rab11-dependent processes, particularly in recycling endosomes and cytokinesis. Its structural features include a conserved TBC domain (residues 201-377) critical for Rab-GAP activity and a less-characterized N-terminal region that may mediate protein interactions or localization.
Antibodies against TBC1D13 are widely used to study its expression, localization, and function in cellular models. They enable applications like Western blotting, immunofluorescence, and immunoprecipitation, aiding in investigations of membrane trafficking, autophagy, and cell division. Research has linked TBC1D13 dysregulation to metabolic disorders and cancer, though its precise pathological roles remain under exploration. Commercial antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat samples. Cross-reactivity with homologous TBC proteins is a potential concern, necessitating careful validation via knockout controls. These tools are essential for dissecting TBC1D13's role in cellular homeostasis and disease mechanisms.
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