Rabbit Polyclonal ZNF516 Antibody

The ZNF516 antibody is a tool used to detect ZNF516 (Zinc Finger Protein 516), a transcription factor belonging to the zinc finger protein family. ZNF516 contains multiple C2H2-type zinc finger motifs, enabling its interaction with DNA or other proteins to regulate gene expression. Studies suggest ZNF516 plays roles in cellular processes such as differentiation, apoptosis, and tumor suppression. For instance, it has been implicated in suppressing breast cancer metastasis by modulating epithelial-mesenchymal transition (EMT) and inhibiting lung cancer progression through interaction with the Wnt/β-catenin signaling pathway. Researchers utilize ZNF516 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression patterns, subcellular localization, and functional mechanisms in both normal and diseased tissues. These antibodies are typically validated for specificity and affinity, often targeting unique epitopes within the protein's N-terminal or C-terminal regions. Commercial ZNF516 antibodies are available from multiple suppliers, with applications spanning cancer research, developmental biology, and studies on transcriptional regulation. Recent work also explores its potential role in metabolic disorders and neurodegenerative diseases, highlighting its broad relevance in biomedical research.