| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | glypican |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GPC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Mouse Camkk1(CaMKK1)抗体的示例参考文献格式及摘要内容。**请注意，以下内容为示例，并非真实存在的文献**，建议通过学术数据库(如PubMed、Google Scholar)检索最新研究：
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1. **文献名称**: *"Development and Validation of a Monoclonal Antibody Specific for Mouse CaMKK1"*
**作者**: Tanaka A, et al.
**摘要**: 本研究描述了一种针对小鼠CaMKK1蛋白的单克隆抗体的开发，通过免疫印迹(Western blot)和免疫沉淀实验验证其特异性，证明其在多种组织(如脑、肝脏)中的应用潜力。
2. **文献名称**: *"CaMKK1 Expression in Mouse Neuronal Development: Insights from Immunohistochemical Analysis"*
**作者**: Lee S, et al.
**摘要**: 利用特异性抗小鼠CaMKK1抗体进行免疫组化分析，揭示了该激酶在小鼠海马神经元分化中的时空表达模式，提示其参与神经突触可塑性调控。
3. **文献名称**: *"Role of CaMKK1 in Hepatic Energy Metabolism: Evidence from Antibody-Based Knockdown Studies"*
**作者**: Rodriguez M, et al.
**摘要**: 通过抗小鼠CaMKK1抗体介导的蛋白干扰实验，证实了CaMKK1在肝脏糖异生中的关键作用，并揭示了其与AMPK信号通路的交互机制。
4. **文献名称**: *"Comparative Analysis of CaMKK Isoforms in Mouse Models Using Isoform-Specific Antibodies"*
**作者**: Gupta R, et al.
**摘要**: 研究比较了CaMKK1与CaMKK2在小鼠组织中的分布差异，通过特异性抗体验证了两种亚型在代谢和应激响应中的不同功能。
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**建议**：实际引用时，请使用数据库检索工具，结合关键词“mouse CaMKK1 antibody”、“anti-CaMKK1 mouse”等，筛选涉及抗体验证或应用的文献，并注意检查抗体的商品化信息(如品牌、货号)以确保准确性。
The mouse CAMKK1 (calcium/calmodulin-dependent protein kinase kinase 1) antibody is a critical tool for studying the function and expression of CAMKK1. a serine/threonine kinase involved in calcium signaling pathways. CAMKK1. also known as CaMKKα, acts as an upstream activator of AMP-activated protein kinase (AMPK) and other calcium/calmodulin-dependent kinases (CaMKs), such as CaMKI and CaMKIV. It plays a pivotal role in regulating cellular processes like energy metabolism, cell growth, autophagy, and neuronal signaling.
Mouse CAMKK1 antibodies are typically designed to detect endogenous CAMKK1 protein in mouse tissues or cell lines. They are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). These antibodies aid in elucidating CAMKK1's tissue-specific _expression (e.g., high levels in brain, liver, and testes) and its involvement in diseases like metabolic disorders, neurodegenerative conditions, and cancer.
Specificity is a key consideration, as CAMKK1 shares structural homology with its isoform CAMKK2 (CaMKKβ). High-quality antibodies are validated using knockout controls to ensure minimal cross-reactivity. Researchers rely on these antibodies to explore CAMKK1's regulatory mechanisms, including its activation by calcium signaling and its role in stress responses, making them indispensable in neuroscience, endocrinology, and cancer biology studies.
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