| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrator complex subunit 6, Int6, DBI-1, Protein DDX26, Protein deleted in cancer 1, DICE1, INTS6, DBI1, DDX26, DDX26A |
| Entrez GeneID | 26512 |
| WB Predicted band size | 100.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This INTS6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 135-167 amino acids from human INTS6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于INTS6 (N-Term)抗体的3篇参考文献示例(注：部分文献为虚构示例，实际引用时需核实原文)：
1. **文献名称**：*"Integrator subunit 6 is required for RNA polymerase II transcription termination and pre-mRNA cleavage"*
**作者**：Tatomer et al.
**摘要**：研究通过生成针对INTS6 N端结构域的特异性抗体，验证其在整合复合体中的功能，揭示INTS6在RNA聚合酶II转录终止和pre-mRNA剪切中的关键作用。
2. **文献名称**：*"INTS6 regulates the DNA damage response through modulation of BRCA1 stability"*
**作者**：Li et al.
**摘要**：利用INTS6 (N-Term)抗体进行免疫沉淀和Western blot分析，发现INTS6通过调控BRCA1蛋白稳定性参与DNA损伤修复通路，提示其潜在肿瘤抑制功能。
3. **文献名称**：*"Characterization of the Integrator complex in embryonic stem cell differentiation"*
**作者**：Smith et al.
**摘要**：通过INTS6 N端抗体的免疫荧光实验，证明INTS6在小鼠胚胎干细胞分化过程中动态定位，并影响多能性相关基因的转录调控。
**注意**：以上文献为示例性内容，实际研究需通过PubMed、Google Scholar等平台以关键词“INTS6 antibody”或“INTS6 N-Terminal”检索真实文献。部分商业抗体公司(如Abcam、Cell Signaling)也可能提供引用其抗体的相关论文列表。
The INTS6 (N-Term) antibody targets the N-terminal region of Integrator Complex Subunit 6 (INTS6), a protein component of the Integrator complex. This evolutionarily conserved multi-subunit complex is associated with RNA polymerase II and plays diverse roles in RNA processing, including the 3' end maturation of small nuclear RNAs (snRNAs) and transcription termination of select genes. INTS6. also known as DDX26B or DICE1. is implicated in transcriptional regulation, DNA damage response, and tumor suppression. Studies suggest its involvement in modulating Wnt/β-catenin signaling and repressing telomerase activity, linking it to cancer progression and cellular senescence.
The N-terminal region of INTS6 contains critical functional domains that mediate protein-protein interactions within the Integrator complex. Antibodies targeting this region are valuable tools for studying INTS6's expression, localization, and molecular interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of INTS6 has been observed in various cancers, including lung, liver, and breast carcinomas, where it often exhibits tumor-suppressive properties. Research using INTS6 (N-Term) antibodies contributes to elucidating its role in transcriptional control, genome stability, and cancer biology, highlighting its potential as a therapeutic target or diagnostic marker.
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