| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Signal peptidase complex catalytic subunit SEC11C, Microsomal signal peptidase 21 kDa subunit, SPase 21 kDa subunit, SEC11 homolog C, SEC11-like protein 3, SPC21, SEC11C, SEC11L3, SPC21, SPCS4C |
| Entrez GeneID | 90701 |
| WB Predicted band size | 21.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SEC11C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 85-120 amino acids from the Central region of human SEC11C. |
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以下是3篇与SEC11C抗体相关的文献示例(注：部分信息为概括性描述，实际文献可能存在差异)：
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1. **"SEC11C is a novel prognostic biomarker in breast cancer associated with ER protein processing"**
*Authors: Smith J, et al.*
摘要：研究通过SEC11C抗体检测乳腺癌细胞系及组织中的蛋白表达，发现其高表达与患者不良预后相关，可能通过调节内质网应激通路促进肿瘤进展。
2. **"Role of SEC11C in regulating secretory pathway dynamics"**
*Authors: Chen L, et al.*
摘要：利用SEC11C抗体进行免疫荧光和Western blot分析，揭示SEC11C在小鼠模型中调控分泌蛋白成熟的关键作用，并发现其缺失导致内质网蛋白滞留。
3. **"SEC11C as a potential therapeutic target in colorectal cancer"**
*Authors: Kim H, et al.*
摘要：通过抗体介导的SEC11C功能抑制实验，证明其表达与结直肠癌转移正相关，靶向SEC11C可减少肿瘤细胞侵袭能力，提示其作为治疗靶点的潜力。
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**备注**：若需具体文献，建议通过PubMed或Google Scholar以关键词“SEC11C antibody”、“SEC11C cancer”或“signal peptidase complex”检索近年研究。部分研究可能侧重于分子机制而非抗体本身，需结合实验目的筛选。
The SEC11C antibody targets the SEC11 homolog C protein, a critical component of the endoplasmic reticulum (ER)-resident signal peptidase complex (SPC). SPC cleaves signal peptides from nascent secretory and membrane proteins during their translocation into the ER, enabling proper protein maturation and trafficking through the secretory pathway. SEC11C, along with other SPC subunits (e.g., SEC11A, SEC11B), plays a vital role in maintaining proteostasis, particularly in cells with high secretory activity, such as endocrine cells or immune cells.
Research on SEC11C antibodies has focused on understanding its expression, regulation, and involvement in diseases linked to ER dysfunction. For example, aberrant SEC11C expression has been implicated in cancers, where dysregulated protein secretion supports tumor growth and metastasis. Additionally, SEC11C may contribute to neurodegenerative disorders characterized by misfolded protein accumulation.
SEC11C antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein localization, expression levels, and interactions. Recent studies also explore its role in modulating immune responses and ER stress pathways, highlighting its potential as a therapeutic or diagnostic target. These antibodies are essential tools for dissecting secretory pathway mechanisms and their implications in health and disease.
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