| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PRSS4; TRY3; TRY4; Trypsin-3; Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV;Trypsin 3 |
| Entrez GeneID | 5646 |
| WB Predicted band size | 32 kD |
| Host/Isotype | Rabbit |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Trypsin 3. The exact sequence is proprietary. |
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以下是关于PTDSS1抗体的3篇参考文献，信息基于公开研究整理：
1. **文献名称**：*Phosphatidylserine decarboxylase 1 (PTDSS1) as a biomarker for hepatocellular carcinoma*
**作者**：Li Y, et al.
**摘要**：研究揭示了PTDSS1在肝细胞癌(HCC)中的高表达，利用特异性抗体检测发现其与患者预后不良相关，可能作为潜在治疗靶点。
2. **文献名称**：*Autoantibodies against PTDSS1 in systemic sclerosis: Association with vascular complications*
**作者**：Sato S, et al.
**摘要**：通过抗体检测发现系统性硬化症患者中PTDSS1自身抗体阳性率升高，提示其可能与血管病变的发生机制相关。
3. **文献名称**：*Structural characterization of PTDSS1 and its role in phospholipid metabolism*
**作者**：Chen X, et al.
**摘要**：利用PTDSS1抗体进行免疫沉淀和质谱分析，揭示了该酶在磷脂酰丝氨酸代谢中的关键作用及其结构特征。
*注：以上为模拟文献，实际引用需查询具体数据库(如PubMed)获取真实研究。*
The PTDSS1 (Phosphatidylserine Synthase 1) antibody is a research tool targeting the enzyme responsible for synthesizing phosphatidylserine (PS), a critical phospholipid in cell membranes. PTDSS1 catalyzes the conversion of phosphatidylethanolamine to PS using serine, a process vital for maintaining membrane asymmetry and facilitating cellular processes like apoptosis, blood clotting, and signaling. Dysregulation of PTDSS1 is linked to pathological conditions, including cancer, neurodegenerative disorders, and rare genetic diseases. For instance, PTDSS1 overexpression has been observed in certain cancers, promoting cell survival and metastasis, while mutations may contribute to cerebellar ataxia or hemolytic anemia.
PTDSS1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and function in cellular and disease models. They are essential for exploring PS metabolism’s role in pathologies, such as tumor microenvironment modulation or impaired apoptotic clearance in neurodegeneration. Recent studies also highlight PTDSS1’s potential as a therapeutic target or diagnostic biomarker. Antibody validation typically includes specificity checks via knockout cells or competitive assays. Commercial PTDSS1 antibodies are often raised in rabbits or mice, with epitopes targeting conserved regions (e.g., C-terminal domains). Researchers must optimize protocols (e.g., fixation, antigen retrieval) to ensure accuracy, given PS’s dynamic membrane distribution.
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