关键信息
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基因名
DRD3
- 应用
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别名
DRD3；D(3) dopamine receptor
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种属
Human
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表达系统
E. coli
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标签
His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35462
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表达区间
1-400aa
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氨基酸序列
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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分子量
44.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Dopamine receptor D3 (DRD3) is a crucial member of the D2-like dopamine receptor family that plays a significant role in the central nervous system, particularly in modulating dopamine signaling related to mood, cognition, and reward pathways. Its involvement in various neuropsychiatric disorders, including schizophrenia, depression, and drug addiction, makes it a target of intensive research. The study of DRD3 has been hampered by challenges in obtaining sufficient quantities of functional receptor protein for structural and biochemical analyses. Recombinant protein techniques have emerged as valuable tools in this context, allowing scientists to produce DRD3 in heterologous systems such as bacteria, yeast, or mammalian cells. By using these methodologies, researchers can better understand the receptor's structure-function relationships, investigate its interactions with ligands and signaling partners, and potentially discover innovative therapeutic agents that specifically target DRD3. Moreover, studying the recombinant DRD3 protein facilitates high-throughput screening and provides insight into receptor activation mechanisms, which are critical for the development of drugs aimed at modulating dopaminergic pathways. As our understanding of DRD3 expands through recombinant protein studies, it holds promise for advancing treatment strategies for various dopamine-related disorders and enhancing our grasp of its physiological roles in the brain.
