Rabbit Polyclonal MouseSrms Antibody

Mouse Srms (Src-related kinase lacking regulatory domains and membrane localization signals) is a non-receptor tyrosine kinase belonging to the Src family kinases (SFKs). Initially identified in the 1990s, Srms shares structural homology with other SFKs but lacks critical regulatory domains, including the C-terminal inhibitory phosphorylation site and a myristoylation signal for membrane anchoring. This unique structure suggests distinct regulatory mechanisms compared to canonical SFKs like Src or Fyn. Srms is primarily expressed in epithelial tissues and immune cells, implicating roles in cell signaling, differentiation, and immune responses. Studies link Srms to phosphorylation-mediated signaling pathways, though its precise biological functions remain less characterized than other SFKs. Research on Srms antibodies has been driven by interest in understanding its atypical signaling behavior and potential involvement in diseases like cancer or autoimmune disorders. These antibodies enable detection of Srms expression, localization, and activity in cells or tissues, often used in techniques such as Western blotting, immunohistochemistry, or flow cytometry. Recent work also explores Srms interactions with substrates like β-catenin, hinting at cross-talk with Wnt signaling. Despite limited literature, Srms antibodies remain valuable tools for unraveling its understudied contributions to cellular physiology and pathology.