| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2, Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2, Protein FAM77B, T-cell lymphoma breakpoint-associated target protein 1, NKAIN2, FAM77B, TCBA1 |
| Entrez GeneID | 154215 |
| WB Predicted band size | 23.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This NKAIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human NKAIN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NKAIN2抗体的示例参考文献(注：部分内容为示例性概括，建议通过学术数据库核实真实文献)：
1. **文献名称**：*NKAIN2 Expression in Schizophrenia: A Post-Mortem Brain Study*
**作者**：Smith A, et al.
**摘要**：通过免疫组化和Western blot分析精神分裂症患者脑组织中NKAIN2蛋白表达，发现前额叶皮层中NKAIN2水平显著降低，提示其可能参与疾病相关的离子通道调控异常。
2. **文献名称**：*Developmental Role of NKAIN2 in Neuronal Migration*
**作者**：Johnson B, et al.
**摘要**：利用NKAIN2抗体进行小鼠胚胎脑组织免疫荧光染色，揭示NKAIN2在神经元迁移中的关键作用，并发现其与钠钾泵亚基的共定位。
3. **文献名称**：*NKAIN2 Interaction with Na+/K+-ATPase in Epithelial Cells*
**作者**：Lee C, et al.
**摘要**：通过免疫共沉淀和Western blot技术，验证NKAIN2抗体特异性，证明NKAIN2与钠钾泵α亚基直接结合，影响离子转运功能。
4. **文献名称**：*Epigenetic Regulation of NKAIN2 in Bipolar Disorder*
**作者**：Zhang Y, et al.
**摘要**：结合甲基化分析与蛋白质检测，发现双相情感障碍患者外周血细胞中NKAIN2表达下调，抗体验证结果支持其表观遗传调控机制。
**提示**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台以关键词“NKAIN2 antibody”或“NKAIN2 protein”检索最新成果。
The NKAIN2 (Na+/K+ Transporting ATPase Interacting 2) antibody is a tool used to study the NKAIN2 protein, part of a conserved eukaryotic protein family implicated in ion transport regulation and neuronal signaling. NKAIN2 interacts with Na+/K+-ATPase, a critical enzyme maintaining cellular electrochemical gradients. While its precise molecular function remains unclear, NKAIN2 is hypothesized to modulate ion channel activity or stabilize membrane protein complexes, influencing neuronal excitability and synaptic transmission.
Research links NKAIN2 to neuropsychiatric and neurodegenerative disorders. Genome-wide studies associate NKAIN2 polymorphisms with conditions like major depressive disorder, schizophrenia, and Parkinson’s disease, suggesting its role in neurological pathways. Additionally, altered NKAIN2 expression has been observed in certain cancers, though its oncogenic or tumor-suppressive mechanisms are under investigation.
The NKAIN2 antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in tissues or cell lines. Antibody validation often includes knockout controls or siRNA knockdown to confirm specificity. Commercial antibodies are typically raised in rabbits or mice using peptide antigens corresponding to conserved regions of human NKAIN2.
Despite its utility, challenges remain in fully characterizing NKAIN2's functional roles, necessitating further studies to elucidate its physiological and pathological relevance.
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