Rabbit Polyclonal PDPR Antibody

The PDPR (Plasma Membrane Depolarization-Regulated Protein) antibody is a tool used to study the PDPR protein, a transmembrane glycoprotein implicated in cellular signaling and membrane potential regulation. First identified in neuronal and endocrine tissues, PDPR is thought to play a role in coupling membrane depolarization to intracellular processes, such as calcium signaling or neurotransmitter release. Structurally, it contains multiple extracellular leucine-rich repeats and a cytoplasmic PDZ-binding domain, suggesting interactions with scaffolding proteins or ion channels. Research on PDPR has expanded into cancer biology, where its aberrant expression correlates with tumor progression and metastasis, possibly through modulating cell adhesion or survival pathways. The PDPR antibody enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in mechanistic studies of its function. However, its biological roles remain incompletely understood, partly due to overlapping functions with related proteins and tissue-specific expression patterns. Current studies focus on clarifying PDPR’s involvement in neurological disorders, metabolic regulation, and oncogenic pathways, leveraging the antibody as a critical reagent for target validation and pathway analysis.