| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1 |
| Entrez GeneID | 659 |
| WB Predicted band size | 115.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27~56 amino acids from the N-terminal region of human BMPR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于BMPR2(N-term)抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
1. **文献名称**: "BMPR2 expression in pulmonary arterial hypertension: Role of promoter methylation and miR-376a"
**作者**: Yan L. et al.
**摘要**: 研究通过Western blot(使用N端特异性BMPR2抗体)发现肺动脉高压患者肺组织中BMPR2蛋白表达显著下调，与启动子甲基化和miR-376a过表达相关，揭示了表观遗传调控在疾病中的作用。
2. **文献名称**: "Functional analysis of BMPR2 mutations in hereditary pulmonary arterial hypertension"
**作者**: Machado R.D. et al.
**摘要**: 利用针对BMPR2 N端的抗体进行免疫沉淀实验，验证了遗传性肺动脉高压患者中BMPR2突变体导致受体二聚化异常，破坏BMP/Smad信号通路，为突变致病机制提供证据。
3. **文献名称**: "Antibody-based profiling of BMPR2 isoforms in vascular remodeling"
**作者**: Wilkins M.R. et al.
**摘要**: 开发了一种特异性识别BMPR2 N端结构域的抗体，用于流式细胞术和免疫组化，发现血管平滑肌细胞中BMPR2亚型在缺氧诱导的重塑过程中动态变化，提示其调控血管稳态的功能。
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**备注**：以上文献为模拟示例，实际引用需根据具体研究查询PubMed或学术数据库。若需真实文献，可补充抗体货号(如Abcam #ab78422)查找其引用论文。
The BMPR2 (N-term) antibody is a tool used to detect the N-terminal region of Bone Morphogenetic Protein Receptor Type II (BMPR2), a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. BMPR2 plays a critical role in mediating cellular responses to bone morphogenetic proteins (BMPs), which regulate diverse processes, including cell proliferation, differentiation, apoptosis, and tissue homeostasis. The receptor forms heteromeric complexes with BMP type I receptors, activating downstream Smad-dependent and non-Smad signaling pathways.
Mutations in the BMPR2 gene are strongly associated with heritable pulmonary arterial hypertension (PAH) and approximately 20% of idiopathic PAH cases, highlighting its importance in vascular remodeling and endothelial function. The N-terminal extracellular domain of BMPR2 is involved in ligand binding and receptor complex assembly. Antibodies targeting this region are widely used in research applications, such as Western blotting, immunohistochemistry, and immunofluorescence, to study BMPR2 expression, localization, and post-translational modifications.
These antibodies help elucidate BMPR2's role in developmental biology, disease mechanisms (particularly PAH), and potential therapeutic targets. They may also distinguish between full-length receptors and truncated isoforms, which is critical in understanding functional variations in pathological conditions. Commercial BMPR2 (N-term) antibodies are typically validated for specificity across human, mouse, and rat samples, supporting translational studies in both basic and clinical research.
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