| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat domain-containing protein 37, Low-density lipoprotein receptor-related protein 2-binding protein, hLrp2bp, ANKRD37, LPR2BP |
| Entrez GeneID | 353322 |
| WB Predicted band size | 16.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANKRD37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-157 amino acids from the C-terminal region of human ANKRD37. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ANKRD37(C-term)抗体的模拟参考文献示例(基于常见研究主题的合理推测)：
1. **文献名称**：*ANKRD37 modulates hypoxia-induced cellular responses via C-terminal domain interactions*
**作者**：Chen L, et al.
**摘要**：本研究揭示了ANKRD37在缺氧条件下的表达调控机制，通过其C端结构域与HIF-1α的相互作用促进肿瘤细胞存活。研究使用ANKRD37(C-term)抗体进行免疫共沉淀和Western blot分析，证实其C端在缺氧信号通路中的关键作用。
2. **文献名称**：*Characterization of ANKRD37 as a novel stress-responsive protein in placental development*
**作者**：Smith J, et al.
**摘要**：本文首次报道ANKRD37在胎盘发育中的功能，其C端结构域在氧化应激条件下调控细胞凋亡。通过ANKRD37(C-term)抗体的免疫组化实验，发现其在妊娠早期胎盘滋养层细胞中高表达，提示其参与母胎界面的应激适应。
3. **文献名称**：*Proteomic identification of ANKRD37-binding partners using C-terminal-specific antibodies*
**作者**：Wang Y, et al.
**摘要**：利用ANKRD37(C-term)抗体进行免疫沉淀-质谱分析，鉴定了ANKRD37的C端互作蛋白网络，包括热休克蛋白HSP90和转录因子FOXO3.提示其在细胞应激和长寿信号中的双重调控功能。
4. **文献名称**：*ANKRD37 expression correlates with poor prognosis in glioblastoma via C-terminal signaling*
**作者**：Garcia R, et al.
**摘要**：通过ANKRD37(C-term)抗体的免疫荧光和临床样本分析，发现ANKRD37在胶质母细胞瘤中高表达，其C端通过激活PI3K/AKT通路促进肿瘤侵袭，为潜在治疗靶点提供依据。
**注**：以上文献为模拟示例，实际研究中请通过PubMed或Google Scholar检索具体文献。若需真实文献，建议补充ANKRD37相关功能关键词(如缺氧、癌症、蛋白互作)进一步筛选。
The ANKRD37 (Ankyrin Repeat Domain 37) protein is a member of the ankyrin repeat-containing protein family, which plays roles in diverse cellular processes, including transcriptional regulation, cell signaling, and stress responses. ANKRD37 is of particular interest due to its potential involvement in hypoxia-related pathways. Studies suggest it may be regulated by hypoxia-inducible factor 1 (HIF-1α) under low-oxygen conditions, linking it to adaptive responses in ischemic or tumor microenvironments. The C-terminal region of ANKRD37 likely contains functional domains critical for protein-protein interactions or regulatory activity, though its precise biological mechanisms remain under investigation.
The ANKRD37 (C-term) antibody is a polyclonal or monoclonal reagent designed to specifically target the C-terminal epitope of the protein. It enables the detection and localization of ANKRD37 in various experimental applications, such as Western blotting, immunohistochemistry, or immunofluorescence. This antibody is particularly valuable for studying ANKRD37 expression patterns in physiological or pathological contexts, such as cancer, cardiovascular diseases, or cellular stress models. Validation typically includes verification via knockdown/knockout controls, peptide blocking assays, or cross-reactivity tests to ensure specificity. Researchers utilize it to explore ANKRD37's role in hypoxia signaling, its interaction partners, or its potential as a biomarker in disease progression.
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