Rabbit Polyclonal USP17L2 Antibody

The USP17L2 antibody targets the ubiquitin-specific protease 17-like family member 2 (USP17L2), a deubiquitinating enzyme (DUB) involved in regulating protein stability and cellular signaling by removing ubiquitin moieties from substrate proteins. USP17L2 belongs to the USP17 subfamily, which is characterized by tandem repeats in their coding sequences and roles in processes such as cell proliferation, apoptosis, and immune responses. While USP17 family members are implicated in cancer, inflammation, and viral defense, USP17L2’s specific functions remain less defined, though it is hypothesized to modulate pathways like the NF-κB or Wnt signaling cascades. Antibodies against USP17L2 are primarily used in research to detect its expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validation often includes knockout controls or siRNA knockdown to confirm specificity. These tools help explore USP17L2’s potential roles in diseases, particularly its regulatory effects on oncoproteins or immune-related targets. However, commercial availability may be limited due to its lesser-studied status compared to other DUBs. Researchers prioritize cross-reactivity checks due to high homology within the USP17 family.