| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Stimulated by retinoic acid gene 6 protein homolog, STRA6 |
| Entrez GeneID | 64220 |
| WB Predicted band size | 73.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This STRA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-614 amino acids from the C-terminal region of human STRA6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STRA6抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*STRA6 regulates vitamin A homeostasis and determines tumorigenicity in non-small cell lung cancer*
**作者**：Tang XH, Gudas LJ
**摘要**：通过使用STRA6特异性抗体，研究发现STRA6通过调控视黄酸代谢影响肺癌细胞的增殖和转移，其表达水平与患者预后显著相关。
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2. **文献名称**：*Antibody-based targeting of STRA6 retinol-binding protein receptor inhibits cancer cell growth and metastasis*
**作者**：Berry DC, Noy N
**摘要**：开发了一种靶向STRA6的单克隆抗体，实验显示其能阻断视黄醇摄取，抑制乳腺癌细胞的迁移和侵袭能力，提示其治疗潜力。
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3. **文献名称**：*STRA6 modulates hepatic glucose production via retinol signaling in insulin-resistant mice*
**作者**：Gomez FJ et al.
**摘要**：利用STRA6抗体进行组织染色和蛋白分析，发现STRA6通过视黄酸信号通路调节肝脏糖异生，与胰岛素抵抗密切相关。
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注：上述文献为示例，实际引用时建议通过PubMed或Google Scholar以关键词“STRA6 antibody”或“STRA6 receptor”检索最新研究。
STRA6 (Stimulated by Retinoic Acid 6) is a transmembrane receptor primarily known for its role in cellular uptake of retinol (vitamin A) through binding to retinol-binding protein 4 (RBP4). Discovered in 2007. it is encoded by the *STRA6* gene and is distinct from other retinol transporters due to its dual functionality as both a transport protein and a signaling mediator. Structurally, STRA6 contains nine transmembrane domains and facilitates retinol transport by interacting with RBP4 on the cell surface, releasing retinol into cells for conversion to retinoic acid (RA), a critical molecule in embryonic development, cell differentiation, and immune regulation.
Beyond transport, STRA6 activates intracellular signaling pathways, notably the JAK/STAT cascade, independent of retinol uptake. This signaling role links STRA6 to cell proliferation, apoptosis, and inflammation. Dysregulation of STRA6 is implicated in developmental disorders, such as Matthew-Wood syndrome (characterized by eye, lung, and heart defects), and diseases like cancer, diabetes, and metabolic syndrome. In cancer, STRA6 may act as an oncogene, promoting tumor growth and metastasis via RA-dependent and independent mechanisms.
STRA6 antibodies are essential tools for studying its expression, localization, and function in tissues. They are used in techniques like Western blot, immunohistochemistry, and flow cytometry to explore STRA6's role in health and disease. Research on STRA6 antibodies also supports therapeutic development, particularly in targeting RA signaling pathways or STRA6-associated pathologies. Despite progress, its pleiotropic roles and regulatory mechanisms remain areas of active investigation.
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