Rabbit Polyclonal GABRG3(N-term) Antibody

The GABRG3 (N-term) antibody is a specialized immunological tool designed to target the N-terminal region of the gamma-3 subunit (γ3) of the GABA_A receptor, a critical component of the inhibitory neurotransmitter system in the central nervous system. GABA_A receptors are ligand-gated chloride channels that mediate fast synaptic inhibition, and their subunit composition (e.g., α, β, γ subunits) determines receptor function, pharmacology, and localization. The γ3 subunit, encoded by the *GABRG3* gene, is less commonly expressed than γ1 or γ2 subunits but plays roles in synaptic plasticity, neurodevelopment, and modulating receptor kinetics. The N-terminal domain of γ3 is essential for receptor assembly, ligand binding, and interaction with other subunits or regulatory proteins. This antibody is typically used in research applications such as Western blotting, immunohistochemistry, or immunofluorescence to study γ3 expression, localization, or alterations in neurological disorders like epilepsy, schizophrenia, or autism spectrum disorders. Its specificity for the N-terminal region ensures recognition of full-length or mature γ3 protein, avoiding cross-reactivity with truncated isoforms. Validation often includes knockout controls or peptide blocking assays to confirm target specificity. Studies utilizing this antibody contribute to understanding GABA_A receptor diversity and their dysfunction in disease.