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Rabbit Polyclonal SUV4-20H1 Antibody

  • 中文名： SUV4-20H1抗体
  • 别    名： Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B
货号: IPDX34996
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHistone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B
Entrez GeneID51111
WB Predicted band size99.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SUV4-20H1抗体的3篇文献摘要概述：

1. **文献名称**: *SUV4-20H1 mediates H4K20 methylation at pericentric heterochromatin*

**作者**: Schotta G, et al.

**摘要**: 该研究揭示了SUV4-20H1作为组蛋白甲基转移酶，特异性催化H4K20的二甲基化和三甲基化，靶向作用于异染色质区域，调控染色质压缩和基因组稳定性。研究通过抗体染色和基因敲除实验证实其功能。

2. **文献名称**: *The role of SUV4-20H1 in DNA damage response and cancer progression*

**作者**: Tardat M, et al.

**摘要**: 文章发现SUV4-20H1通过修饰H4K20me3参与DNA损伤修复机制，其表达异常与多种癌症相关。研究利用SUV4-20H1抗体进行免疫印迹和免疫荧光，证明其在肿瘤细胞中的功能缺失导致基因组不稳定。

3. **文献名称**: *Epigenetic regulation by SUV4-20H1 in embryonic stem cell differentiation*

**作者**: Beck DB, et al.

**摘要**: 该研究探讨SUV4-20H1在胚胎干细胞分化中的表观调控作用，发现其通过调控H4K20me3水平影响基因沉默和分化进程。实验通过ChIP-seq(使用SUV4-20H1抗体)揭示其靶向基因位点。

注：以上文献为示例性概括，实际引用需根据具体研究补充完整信息(年份、期刊等)。如需精确文献，建议通过PubMed或Google Scholar以关键词“SUV4-20H1 antibody”或“H4K20me3”检索近期研究。

背景信息

The SUV4-20H1 antibody targets the SUV4-20H1 protein, a histone methyltransferase responsible for catalyzing the trimethylation of lysine 20 on histone H4 (H4K20me3), a post-translational modification critical for chromatin organization and genome stability. SUV4-20H1. along with its paralog SUV4-20H2. belongs to the SU(VAR)4-20 family of enzymes, which are evolutionarily conserved and play roles in heterochromatin formation, DNA repair, and mitotic progression. H4K20me3 is enriched in constitutive heterochromatin, such as pericentric regions and telomeres, and serves as a docking site for proteins involved in chromatin compaction and transcriptional silencing. Dysregulation of SUV4-20H1 activity or H4K20me3 levels has been implicated in developmental disorders, cellular senescence, and cancer, as aberrant heterochromatin states can lead to genomic instability or oncogenic gene expression. The SUV4-20H1 antibody is widely used in epigenetics research to study chromatin dynamics, DNA damage response, and cell cycle regulation through techniques like ChIP-seq, immunofluorescence, and Western blotting. Its specificity makes it a valuable tool for exploring the functional interplay between histone modifications, nuclear architecture, and disease mechanisms.

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