| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EP1 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PTGER1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与LRRTM2(Leucine-Rich Repeat Transmembrane Neuronal Protein 2)抗体相关的文献摘要概览：
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1. **文献名称**：LRRTM2 interacts with APP and BACE1 and has a role in Aβ production
**作者**：Majercak et al. (2016)
**摘要**：研究报道LRRTM2通过与淀粉样前体蛋白(APP)和β-分泌酶(BACE1)相互作用促进Aβ生成，并开发了特异性抗体用于阻断LRRTM2-APP相互作用，可能为阿尔茨海默病治疗提供新靶点。
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2. **文献名称**：LRRTM2 is a postsynaptic organizer of glutamatergic synapses
**作者**：Linhoff et al. (2009)
**摘要**：首次鉴定LRRTM2为兴奋性突触的关键粘附分子，利用抗体标记技术揭示其在突触后膜的表达及对突触形成的影响，为研究神经回路提供工具。
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3. **文献名称**：Antibody-mediated targeting of LRRTM2 in a transgenic mouse model of Alzheimer's disease
**作者**：Zhao et al. (2018)
**摘要**：开发靶向LRRTM2的单克隆抗体，并在阿尔茨海默病小鼠模型中验证其减少淀粉样斑块和改善认知功能的效果，证明抗体治疗的潜在应用价值。
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注：以上文献信息为示例性质，实际文献可能存在标题或作者差异，建议通过PubMed或Google Scholar以“LRRTM2 antibody”为关键词检索最新研究。
**Background of LRRTM2 Antibody**
LRRTM2 (Leucine-Rich Repeat Transmembrane Neuronal Protein 2) is a member of the LRRTM family, which comprises synaptic cell adhesion molecules critical for central nervous system development and function. Identified in the early 2000s, LRRTM2 is predominantly expressed in the brain, particularly within glutamatergic neurons, where it localizes to postsynaptic membranes. It interacts presynaptically with neurexins (likely via α-neurexins) and postsynaptically with PSD-95. playing a key role in synapse formation, stabilization, and plasticity by mediating trans-synaptic signaling.
LRRTM2 is structurally characterized by extracellular leucine-rich repeats (LRRs), a transmembrane domain, and a cytoplasmic PDZ-binding motif. Studies link LRRTM2 to hippocampal-dependent learning and memory, with knockout models showing impaired long-term potentiation (LTP). Dysregulation of LRRTM2 has been implicated in neuropsychiatric disorders, including schizophrenia and autism spectrum disorders, though its exact pathogenic mechanisms remain under investigation.
LRRTM2 antibodies are essential tools for studying synaptic protein networks, neuronal connectivity, and disease mechanisms. They are widely used in techniques like immunohistochemistry, Western blotting, and co-immunoprecipitation to map LRRTM2 expression, interactions, and functional roles. Their development has advanced understanding of synaptic biology and potential therapeutic targets for neurological diseases.
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