Rabbit Polyclonal NDUFAB1 Antibody

NDUFAB1 antibody is a crucial tool for studying the mitochondrial complex I (NADH:ubiquinone oxidoreductase), a key component of the electron transport chain (ETC) responsible for ATP production. The NDUFAB1 gene encodes a subunit of complex I, specifically the acyl carrier protein (ACP), which is essential for both the structural integrity and enzymatic activity of the complex. This protein plays a dual role: it participates in electron transfer reactions and contributes to the biosynthesis of lipoic acid, a cofactor required for mitochondrial metabolism. Mutations or dysregulation of NDUFAB1 are linked to mitochondrial disorders, such as Leigh syndrome, and have been implicated in neurodegenerative diseases, cancer, and metabolic syndromes. Antibodies targeting NDUFAB1 enable researchers to detect protein expression levels, assess complex I assembly, and investigate mitochondrial dysfunction in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific expression, subcellular localization, and protein interactions. Commercial NDUFAB1 antibodies are typically raised in hosts like rabbits or mice, with validation via knockout controls or siRNA knockdown to ensure specificity. These reagents are vital for advancing research into mitochondrial biology, energy metabolism, and therapeutic strategies targeting ETC deficiencies.