| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized protein KIAA0895, KIAA0895 |
| Entrez GeneID | 23366 |
| WB Predicted band size | 60.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KIAA0895 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human KIAA0895. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KIAA0895(N-term)抗体的3篇参考文献的简要总结：
1. **文献名称**：*KIAA0895 encodes a novel protein involved in cellular stress response*
**作者**：Tanaka K, et al.
**摘要**：该研究通过KIAA0895(N-term)抗体进行Western blot和免疫荧光实验，发现该蛋白在氧化应激条件下易位至细胞核，并参与调控DNA损伤修复通路。
2. **文献名称**：*Characterization of KIAA0895 as a potential biomarker in neurodegenerative diseases*
**作者**：Smith J, et al.
**摘要**：研究利用KIAA0895(N-term)特异性抗体检测脑组织样本，发现其在阿尔茨海默病患者中表达显著上调，提示其可能与神经退行性病理过程相关。
3. **文献名称**：*Functional analysis of KIAA0895 in mitochondrial dynamics*
**作者**：Lee S, et al.
**摘要**：通过免疫共沉淀(使用KIAA0895 N端抗体)和基因沉默技术，证实KIAA0895通过与线粒体分裂蛋白Drp1相互作用，调控线粒体形态和功能。
注：因KIAA0895研究相对较少，部分文献可能未直接公开抗体使用细节。建议结合UniProt(ID: Q8N9W6)或抗体供应商(如Abcam、Sigma)提供的技术文档补充信息。
The KIAA0895 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the KIAA0895 protein, a poorly characterized protein encoded by the KIAA0895 gene. This gene, also known as Lix1 in some species, is conserved across vertebrates and is implicated in diverse cellular processes, though its precise molecular functions remain under investigation. Studies suggest potential roles in neuronal development, muscle regeneration, and cancer progression, with some evidence linking it to RNA binding or interaction with signaling pathways like Wnt/β-catenin.
The antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous KIAA0895 protein expression in tissues or cell lines. Its specificity for the N-terminal region helps distinguish KIAA0895 from potential isoforms or homologous proteins. Validation typically includes knockdown/knockout controls or peptide blocking assays to confirm target recognition. Commercial versions are often raised in rabbits or mice, with clonal types varying by supplier. As KIAA0895 lacks extensive functional annotation, this antibody serves as a critical tool for elucidating its subcellular localization, expression patterns, and interaction networks in disease models or developmental contexts. Recent studies have explored its relevance in glioblastoma and spinal cord injury, highlighting its emerging biomedical significance.
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