| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Complement component receptor 1-like protein, Complement C4b-binding protein CR-1-like protein, CR1L |
| Entrez GeneID | 1379 |
| WB Predicted band size | 62.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human CR1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CR1L(C-term)抗体的3篇示例参考文献(注：内容为模拟生成，实际文献需通过学术数据库检索)：
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1. **标题**: *"Characterization of a Novel CR1L C-terminal Antibody for Detecting Isoform-Specific Expression in Human Tissues"*
**作者**: Smith A, et al.
**摘要**: 该研究报道了一种针对CR1L蛋白C末端结构域的高特异性多克隆抗体的开发与验证。通过Western blot和免疫组化实验，证明该抗体可特异性识别CR1L的C端异构体，并在肾脏和肝脏组织中检测到其差异表达。
2. **标题**: *"CR1L Function in Complement Regulation: Insights from C-terminal Epitope-Specific Antibodies"*
**作者**: Lee J, et al.
**摘要**: 研究利用CR1L C端抗体分析其在补体系统调控中的作用。实验表明，CR1L通过C末端与补体因子相互作用，抗体阻断实验进一步揭示了其抑制补体激活通路的关键机制。
3. **标题**: *"Development of a Monoclonal Antibody Targeting CR1L C-terminal Domain for Cancer Biomarker Studies"*
**作者**: Garcia R, et al.
**摘要**: 本文描述了一种针对CR1L C末端表位的单克隆抗体的制备，并验证其在结直肠癌组织中的高表达现象。该抗体在ELISA和流式细胞术中表现出高亲和力，提示其作为肿瘤诊断标志物的潜力。
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建议通过 **PubMed** 或 **Google Scholar** 检索关键词 "CR1L C-terminal antibody" 或结合具体研究领域(如补体系统、癌症等)获取真实文献。
**Background of CR1L (C-term) Antibody**
CR1L (Complement Receptor 1-Like), also known as CR1L or CR1-like protein, is a member of the complement receptor family involved in regulating immune responses and inflammation. It shares structural homology with Complement Receptor 1 (CR1), containing short consensus repeat (SCR) domains that mediate interactions with complement components like C3b and C4b. CR1L exists in both membrane-bound and soluble forms, playing roles in complement activation control, immune complex clearance, and cellular signaling.
The CR1L (C-term) antibody specifically targets the C-terminal region of the CR1L protein, enabling the detection and analysis of its expression, localization, and post-translational modifications. This antibody is commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to study CR1L's role in physiological and pathological contexts, including autoimmune diseases, infections, and cancer.
Research applications often focus on CR1L's involvement in modulating complement pathways, its interaction with pathogens or immune cells, and its potential as a biomarker. The antibody's specificity for the C-terminal region ensures minimal cross-reactivity with other complement regulatory proteins like CR1. making it a critical tool for dissecting CR1L-specific functions in both human and model organism studies. Validation typically includes knockout controls to confirm target specificity.
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