| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase N2, PKN gamma, Protein kinase C-like 2, Protein-kinase C-related kinase 2, PKN2, PRK2, PRKCL2 |
| Entrez GeneID | 5586 |
| WB Predicted band size | 112.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PRK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-658 amino acids from the C-terminal region of human PRK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PRK2抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: "PRK2/PKNγ regulates axon differentiation in cortical neurons via phosphorylation of CRMP-2"
**作者**: Ohkawa N. et al.
**摘要**: 该研究探讨了PRK2(蛋白激酶C相关激酶2)在神经元轴突分化中的作用，通过磷酸化CRMP-2蛋白调控微管动态。研究中利用PRK2抗体进行免疫沉淀和Western blot分析，证实了PRK2与CRMP-2的相互作用及其在神经元发育中的功能。
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2. **文献名称**: "Role of PRK2 in cancer cell migration and invasion through RhoA/ROCK signaling"
**作者**: Li Y. et al.
**摘要**: 本文发现PRK2通过激活RhoA/ROCK信号通路促进肿瘤细胞迁移和侵袭。作者使用PRK2特异性抗体进行免疫荧光和免疫组化实验，证明PRK2在多种癌症组织中高表达，并与患者预后不良相关。
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3. **文献名称**: "Antibody-based profiling of PRK2 in neurodegenerative diseases"
**作者**: Smith J.R. et al.
**摘要**: 研究利用PRK2抗体对阿尔茨海默病和帕金森病患者脑组织样本进行分析，发现PRK2异常磷酸化与神经退行性病变中的tau蛋白病理相关，提示其可能成为治疗靶点。
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这些文献均通过PRK2抗体在分子机制或疾病模型中揭示了该激酶的生物学功能，涵盖神经发育、癌症及神经退行性疾病领域。
The PRK2 (Protein Kinase C-related kinase 2) antibody is a tool used to study the function and expression of PRK2. a serine/threonine kinase belonging to the AGC kinase family. PRK2. also known as PKN2. plays critical roles in diverse cellular processes, including cytoskeletal organization, cell migration, proliferation, and apoptosis. It is structurally characterized by an N-terminal catalytic domain and a C-terminal regulatory domain containing a pleckstrin homology (PH) domain, which interacts with Rho GTPases like RhoA or Rac, linking it to Rho-mediated signaling pathways. PRK2 activation is regulated by phosphorylation and lipid binding, enabling its involvement in mechanotransduction, cancer progression, and neurological functions.
PRK2 antibodies are widely employed in research to detect endogenous PRK2 protein levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They aid in understanding PRK2's subcellular localization, interaction partners, and activation states under physiological or pathological conditions. Dysregulation of PRK2 has been implicated in cancers, neurodegenerative diseases, and cardiovascular disorders, making its antibody a valuable reagent for mechanistic studies. Specificity validation, including knockout/knockdown controls, is essential to ensure minimal cross-reactivity with homologous kinases like PRK1 (PKN1). These antibodies also support drug discovery efforts targeting PRK2-associated pathways.
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