| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase STYK1, Novel oncogene with kinase domain, mNOK, Serine/threonine/tyrosine kinase 1, Styk1, Nok |
| Entrez GeneID | 243659 |
| WB Predicted band size | 48.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Styk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of mouse Styk1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于小鼠STYK1抗体的3篇参考文献示例(注：文献为模拟生成，仅供参考)：
1. **文献名称**：*STYK1/NOK promotes tumor cell proliferation in murine glioblastoma models*
**作者**：Li, X. et al.
**摘要**：本研究利用特异性抗小鼠STYK1抗体，通过免疫印迹和免疫组化分析，证实STYK1在胶质瘤细胞中高表达，并促进肿瘤增殖及MAPK通路激活。
2. **文献名称**：*Characterization of a monoclonal antibody against mouse STYK1 kinase domain*
**作者**：Wang, H. & Chen, J.
**摘要**：报道一种靶向小鼠STYK1激酶结构域的单克隆抗体的开发与验证，该抗体可用于流式细胞术及免疫沉淀，成功应用于STYK1敲除小鼠模型的蛋白表达缺失验证。
3. **文献名称**：*STYK1 regulates embryonic stem cell differentiation via FGF signaling*
**作者**：Yamamoto, K. et al.
**摘要**：通过抗STYK1抗体的免疫荧光染色，发现STYK1在小鼠胚胎干细胞中调控FGF信号通路，影响多能性因子Oct4的表达及中胚层分化。
---
**注**：实际文献需通过PubMed、Google Scholar等平台检索关键词“STYK1 antibody mouse”或“anti-STYK1 murine”获取。部分研究可能侧重于抗体应用(如疾病机制)，而非抗体开发本身。
Mouse Styk1 antibody targets the protein Serine/Threonine/Tyrosine Kinase 1 (STYK1), also known as Novel Oncogenic Kinase (NOK), a member of the protein kinase superfamily. Structurally, STYK1 contains a conserved intracellular kinase domain but lacks an extracellular ligand-binding region, distinguishing it from classical receptor tyrosine kinases (RTKs). Its catalytic activity remains debated, with some studies suggesting weak tyrosine kinase activity or functioning as a pseudokinase. STYK1 is implicated in regulating cell proliferation, survival, migration, and tumorigenesis. Overexpression has been observed in various cancers (e.g., breast, lung, gastric), correlating with poor prognosis, metastasis, and chemoresistance. It may interact with signaling pathways like MAPK/ERK and PI3K/AKT.
Mouse Styk1 antibodies are essential tools for detecting and characterizing STYK1 expression in murine models. They enable applications such as Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific localization, expression levels, and post-translational modifications. These antibodies also facilitate functional studies, including knockout validation and mechanistic exploration of STYK1's role in cancer progression or developmental biology. Commercial antibodies are typically generated using immunogenic peptides from conserved regions of the mouse STYK1 protein, with validation steps ensuring specificity against murine homologs. Research using these reagents contributes to understanding STYK1's dual roles in normal physiology and oncogenic transformation.
×
