| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FUN14 domain-containing protein 2, Cervical cancer proto-oncogene 3 protein, HCC-3, Hepatitis C virus core-binding protein 6, FUNDC2, HCBP6 |
| Entrez GeneID | 65991 |
| WB Predicted band size | 20.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FUNDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human FUNDC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FUNDC2抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*FUNDC2 promotes mitophagy by recruiting ULK1 to mitochondria and interacts with LC3 under hypoxic conditions*
**作者**：Chen G. et al. (2019)
**摘要**：该研究通过免疫共沉淀(Co-IP)和Western blot技术，利用FUNDC2抗体证实了其在低氧条件下与自噬标记物LC3的相互作用，并揭示FUNDC2通过招募ULK1至线粒体表面调控线粒体自噬的分子机制。
2. **文献名称**：*Downregulation of FUNDC2 correlates with poor prognosis and immune infiltration in colorectal cancer*
**作者**：Li X. et al. (2021)
**摘要**：研究通过免疫组化(IHC)和Western blot分析，使用FUNDC2抗体检测结直肠癌组织中蛋白表达水平，发现FUNDC2低表达与患者预后不良及肿瘤微环境免疫细胞浸润减少显著相关。
3. **文献名称**：*FUNDC2 regulates mitochondrial dynamics and apoptosis in hepatocellular carcinoma*
**作者**：Wang Y. et al. (2020)
**摘要**：该研究利用FUNDC2抗体进行免疫荧光染色和流式细胞术，证明FUNDC2通过调控线粒体分裂-融合平衡影响肝癌细胞凋亡，其缺失导致线粒体碎片化并促进肿瘤生长。
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**备注**：上述文献为示例，实际引用时需根据具体研究内容核实准确性。若需完整文献，建议通过PubMed或Google Scholar以“FUNDC2 antibody”或“FUNDC2 function”为关键词检索。
The FUNDC2 (FUN14 domain-containing protein 2) antibody is a tool used to detect and study the FUNDC2 protein, a mitochondrial membrane protein implicated in cellular homeostasis and stress responses. Discovered as part of the FUN14 domain-containing protein family, FUNDC2 shares structural homology with FUNDC1. a well-characterized regulator of hypoxia-induced mitophagy. However, FUNDC2's exact biological roles remain less defined. It is proposed to participate in mitochondrial dynamics, energy metabolism, and apoptosis regulation, potentially interacting with autophagy-related proteins like LC3.
Research suggests FUNDC2 overexpression correlates with cancer progression, including tumor growth, metastasis, and chemoresistance in cancers such as hepatocellular carcinoma and colorectal cancer. Its downregulation, conversely, may inhibit proliferation and promote apoptosis in some contexts. The FUNDC2 antibody enables researchers to explore these mechanisms through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also highlight its potential involvement in cardiovascular diseases and neurological disorders, though evidence remains preliminary.
Despite its growing relevance, challenges persist in characterizing FUNDC2 due to its tissue-specific expression patterns and functional diversity across cellular contexts. High-quality, validated FUNDC2 antibodies are critical for clarifying its molecular interactions, post-translational modifications, and therapeutic potential in disease models.
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