Rabbit Polyclonal C15orf37 Antibody

The C15orf37 antibody is a research tool designed to detect the protein encoded by the *C15orf37* (Chromosome 15 Open Reading Frame 37) gene, also known as *LYRA* or *SMIMIC*. This gene is located on human chromosome 15q15.3 and produces a poorly characterized protein implicated in diverse cellular processes. Studies suggest C15orf37 may function as a transmembrane or secreted protein, with potential roles in spermatogenesis (via interaction with SPEF2) and cancer progression. Its overexpression has been observed in melanoma, prostate cancer, and hepatocellular carcinoma, linking it to tumor proliferation and metastasis. The C15orf37 antibody, typically a polyclonal or monoclonal immunoglobulin, enables protein localization (e.g., cytoplasm, cell membrane) and expression analysis in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Despite growing interest, the protein’s precise molecular mechanisms and physiological functions remain unclear. Current research focuses on elucidating its involvement in cancer pathways, cellular signaling, and potential diagnostic/therapeutic applications. Validation of antibody specificity via knockout controls or siRNA is critical due to homology with other proteins and limited characterization data.