| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSP70T; hum70t; HSP70-1L; HSP70-HOM |
| WB Predicted band size | 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSPA1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBN2(N-term)抗体的假设性参考文献示例(请注意，这些文献为模拟内容，实际引用需根据真实研究调整)：
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1. **文献名称**：*UBN2 Facilitates DNA Repair by Modulating Histone Ubiquitination*
**作者**：Smith J, et al.
**摘要**：本研究揭示了UBN2蛋白通过N端结构域与组蛋白H2A相互作用，参与DNA损伤修复机制。作者利用UBN2(N-term)抗体进行免疫沉淀实验，证实其在同源重组修复中的关键作用，并发现UBN2缺失导致基因组不稳定性增加。
2. **文献名称**：*Nuclear Localization and Functional Characterization of UBN2 in Stem Cell Differentiation*
**作者**：Li X, et al.
**摘要**：通过UBN2(N-term)抗体的免疫荧光和Western blot分析，研究者发现UBN2在小鼠胚胎干细胞的细胞核中高表达，并调控多能性基因的沉默。实验表明，UBN2的N端结构域对其核定位及分化过程至关重要。
3. **文献名称**：*UBN2 as a Prognostic Biomarker in Ovarian Cancer*
**作者**：Garcia R, et al.
**摘要**：该研究利用UBN2(N-term)抗体对卵巢癌组织进行免疫组化分析，发现UBN2表达水平与患者生存率呈负相关。进一步功能实验显示，UBN2通过调控染色质重塑促进肿瘤侵袭性。
4. **文献名称**：*Interaction Mapping of UBN2 with Chromatin Remodeling Complexes*
**作者**：Wang Y, et al.
**摘要**：研究者使用UBN2(N-term)抗体进行ChIP-seq分析，揭示了UBN2与SWI/SNF复合物的协同作用，调控特定基因启动子区域的染色质开放状态，从而影响细胞周期进程。
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**提示**：如需真实文献，建议在PubMed或Google Scholar中检索关键词“UBN2 antibody”或“Ubinuclein-2 N-terminal”，并筛选涉及实验应用的论文。抗体厂商(如CST、Abcam)的产品手册也可能提供相关引用。
**Background of UBN2 (N-term) Antibody**
UBN2 (Ubinuclein 2) is a nuclear protein implicated in chromatin remodeling, transcriptional regulation, and cellular differentiation. It interacts with histone-modifying complexes, such as the histone H3K36me2 demethylase KDM2A, to influence gene expression and maintain genomic stability. UBN2 is structurally characterized by a conserved N-terminal region, which mediates protein-protein interactions, and a C-terminal domain involved in chromatin binding. Dysregulation of UBN2 has been linked to cancers, including breast and ovarian tumors, where it may act as a tumor suppressor or oncogene depending on context.
The UBN2 (N-term) antibody specifically targets the N-terminal region of the protein, enabling detection and analysis of UBN2 expression, localization, and function in various experimental settings. This antibody is widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study UBN2’s role in DNA damage response, cell cycle regulation, and epigenetic modifications. Its development has facilitated insights into UBN2’s involvement in pathological processes, particularly cancer progression, and its potential as a therapeutic target. Validation of the antibody includes specificity tests via knockout cell lines or siRNA-mediated knockdown to ensure reliable results.
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