Rabbit Polyclonal SLC9A6 Antibody

The SLC9A6 antibody targets the solute carrier family 9 member A6 (SLC9A6) protein, a sodium/hydrogen exchanger primarily localized to endosomal and mitochondrial membranes. This protein plays a critical role in regulating intracellular pH and ion homeostasis, particularly in neuronal cells. Mutations in the SLC9A6 gene are linked to Christianson syndrome, an X-linked neurodevelopmental disorder characterized by intellectual disability, progressive ataxia, and behavioral abnormalities. Research on SLC9A6 antibodies focuses on understanding the protein's expression patterns, subcellular localization, and functional alterations in disease models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect SLC9A6 in tissues or cultured cells. Studies also employ them to investigate dysregulated endosomal trafficking and mitochondrial dysfunction in neurodevelopmental disorders or neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Commercially available SLC9A6 antibodies include monoclonal and polyclonal variants, often validated for specificity using knockout cell lines or tissue samples. Recent interest has expanded to exploring SLC9A6's role in cancer, where abnormal expression may influence tumor progression. Proper validation remains essential due to potential cross-reactivity with other SLC9 family members.