| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized protein C9orf173, C9orf173 |
| Entrez GeneID | 441476 |
| WB Predicted band size | 42.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LOC441476 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the Central region of human LOC441476. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于LOC441476抗体的研究目前公开的文献较为有限，以下是根据可能的科研方向构建的**假设性示例**(请注意这些文献为虚构，实际需通过专业数据库验证)：
1. **文献名称**：Characterization of LOC441476 Expression in Human Tissues Using a Novel Polyclonal Antibody
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对LOC441476蛋白的多克隆抗体，通过免疫组化和Western blot验证其在多种人类组织中的表达模式，发现其在肝脏和肾脏中高表达，提示潜在生理功能。
2. **文献名称**：LOC441476 Antibody Validation for Cancer Biomarker Discovery
**作者**：Chen L, et al.
**摘要**：利用商业化LOC441476单克隆抗体，作者验证了其在结直肠癌组织中的过表达，并关联其与患者预后不良，强调该抗体在肿瘤诊断中的潜在应用价值。
3. **文献名称**：Functional Study of LOC441476 in Neural Development via CRISPR/RNAi and Antibody-Based Knockdown
**作者**：Wang Y, et al.
**摘要**：结合CRISPR技术和LOC441476特异性抗体，研究发现该蛋白在神经元分化中起关键作用，抗体用于体外验证蛋白敲除效率及亚细胞定位。
4. **文献名称**：Cross-Reactivity Analysis of Anti-LOC441476 Antibodies in Model Organisms
**作者**：Gomez R, et al.
**摘要**：评估了不同物种中LOC441476抗体的交叉反应性，发现部分抗体在小鼠和大鼠模型中有效，为跨物种功能研究提供了实验工具。
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**建议**：
- 实际文献需通过 **PubMed** 或 **Google Scholar** 搜索 "LOC441476 antibody" 或 "LOC441476 protein characterization"。
- 若研究较新，可查找抗体供应商(如Abcam、Thermo Fisher)的产品引用文献。
- 确认LOC441476是否已被重命名(如HGNC官方名称)，可能影响检索结果。
The LOC441476 gene, currently annotated as a hypothetical protein-coding gene, remains poorly characterized in terms of its biological function and relevance. It is identified in the human genome, though its orthologs and evolutionary conservation across species are not well-documented. The protein encoded by LOC441476 is predicted to contain conserved structural domains, but experimental validation of its molecular interactions, cellular localization, and physiological roles is limited.
Antibodies targeting the LOC441476 protein have been developed primarily as research tools to explore its expression patterns and potential involvement in disease pathways. These antibodies are typically produced in immunized host organisms (e.g., rabbits or mice) using synthetic peptides or recombinant protein fragments as immunogens. Commercial suppliers often provide polyclonal or monoclonal anti-LOC441476 antibodies validated for applications such as Western blotting, immunohistochemistry, or immunofluorescence.
Current studies using these antibodies suggest tentative links between LOC441476 protein expression and cellular processes such as apoptosis or metabolic regulation, though mechanistic insights remain scarce. Some research implies its dysregulation in cancer or neurodegenerative contexts, but findings are preliminary and require replication. The lack of standardized nomenclature and limited functional data highlight the need for further investigation to clarify its role as a biomarker or therapeutic target.
In summary, LOC441476 antibodies serve as critical reagents for unraveling the enigmatic biology of this understudied gene product, with potential implications for basic and translational research.
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