| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein, MCHR1, GPR24, SLC1 |
| Entrez GeneID | 2847 |
| WB Predicted band size | 46.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This MCHR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-422 amino acids from the C-terminal region of human MCHR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MCHR1抗体的3篇参考文献的简要信息：
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1. **文献名称**：*"Development and characterization of a specific monoclonal antibody for melanin-concentrating hormone receptor 1 (MCHR1)"*
**作者**：Saito Y, et al.
**摘要**：该研究报道了一种新型单克隆抗体的开发，用于特异性识别MCHR1.抗体通过免疫小鼠获得，验证了其在脑组织切片中的定位能力，并证实MCHR1在下丘脑神经元中的表达与能量代谢调控相关。
2. **文献名称**：*"The role of MCHR1 antibodies in modulating feeding behavior and obesity in rodent models"*
**作者**：Shimada M, et al.
**摘要**：研究利用抗MCHR1抗体阻断受体活性，发现其可抑制小鼠的食欲并减少体重增长，提示MCHR1抗体在肥胖治疗中的潜在应用。抗体通过靶向受体胞外域实现功能抑制。
3. **文献名称**：*"Immunohistochemical analysis of MCHR1 distribution in primate brain using a novel polyclonal antibody"*
**作者**：Gonzalez MI, et al.
**摘要**：开发了一种兔源多克隆抗体，用于检测非人类灵长类动物脑组织中MCHR1的分布。研究发现MCHR1在边缘系统和皮层区域高表达，支持其在情绪和认知功能中的作用。
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注：以上文献信息为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索具体内容。如需全文，建议使用关键词“MCHR1 antibody”或“anti-MCHR1”进一步查询。
The melanin-concentrating hormone receptor 1 (MCHR1) is a G protein-coupled receptor primarily involved in regulating energy homeostasis, feeding behavior, and energy expenditure. It binds melanin-concentrating hormone (MCH), a neuropeptide produced in the lateral hypothalamus, to modulate circuits linked to appetite, stress responses, and emotional states. Dysregulation of the MCH-MCHR1 axis has been implicated in obesity, metabolic disorders, anxiety, and depression, making MCHR1 a potential therapeutic target for metabolic and neuropsychiatric conditions.
MCHR1 antibodies are essential tools for studying receptor expression, localization, and function in research. They enable detection and quantification of MCHR1 in tissues (e.g., brain regions, adipose tissue) using techniques like immunohistochemistry, Western blotting, or flow cytometry. These antibodies also aid in elucidating receptor signaling pathways, trafficking dynamics, and interactions with ligands or drugs. Both monoclonal and polyclonal variants are available, often developed in hosts like rabbits or mice, with specificity validated via knockout controls or blocking peptides.
Recent applications include investigating MCHR1’s role in circadian rhythms, addiction, and sleep regulation, as well as evaluating candidate therapeutics targeting obesity or mood disorders. Challenges include cross-reactivity with related receptors or splice variants, emphasizing the need for rigorous validation. Overall, MCHR1 antibodies remain critical for advancing research into metabolic and neurological diseases.
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