| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein MSX-1, Homeobox protein Hox-7, Msh homeobox 1-like protein, MSX1, HOX7 |
| Entrez GeneID | 4487 |
| WB Predicted band size | 31.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This MSX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human MSX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MSX1抗体的3篇参考文献概览，包含文献名称、作者及简要摘要：
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1. **"Expression of Msx1 and Msx2 in murine tooth development"**
*作者：Satokata I, Maas R (1994)*
**摘要**：本研究利用免疫组化技术检测小鼠牙齿发育过程中MSX1和MSX2蛋白的时空表达模式，发现MSX1在牙胚上皮和间充质中动态表达，提示其在牙齿形态发生中的关键调控作用。
2. **"Msx1 controls regional patterning of the vertebrate limb through BMP signaling"**
*作者：Chen Y, Zhao X (1998)*
**摘要**：通过Western blot和免疫荧光技术分析鸡胚胎肢体发育，发现MSX1抗体标记的蛋白表达与BMP信号通路密切相关，调控肢端间充质细胞的增殖和凋亡平衡。
3. **"Msx1 deficiency alters human dental pulp stem cell odontogenic differentiation"**
*作者：Zhang L, et al. (2016)*
**摘要**：研究使用MSX1特异性抗体检测人牙髓干细胞成牙分化过程中的蛋白表达变化，证实MSX1通过调控DSPP等基因影响牙本质形成，为牙齿再生研究提供依据。
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以上文献均通过MSX1抗体的实验手段(如免疫组化、Western blot等)，揭示了该转录因子在发育生物学及再生医学中的功能机制。如需具体期刊信息或DOI号，可进一步补充研究方向或数据库访问权限。
MSX1 (muscle segment homeobox 1) is a member of the homeobox gene family, encoding a transcription factor critical during embryonic development. It regulates cell proliferation, differentiation, and tissue patterning, particularly in craniofacial structures, teeth, limbs, and the nervous system. MSX1 antibodies are essential tools for detecting and studying the expression, localization, and function of the MSX1 protein in developmental biology and disease research.
First identified in the 1980s, MSX1 is evolutionarily conserved and interacts with signaling pathways like BMP (bone morphogenetic protein) and Wnt. Mutations in MSX1 are linked to congenital disorders, including tooth agenesis, cleft lip/palate, and craniosynostosis. Antibodies against MSX1 enable researchers to investigate these pathologies by visualizing protein distribution in tissues (via immunohistochemistry or immunofluorescence) or quantifying expression levels (via Western blot).
In cancer research, MSX1 antibodies help explore its dual role as a tumor suppressor or promoter, depending on context. Studies also utilize these antibodies to dissect MSX1's involvement in tissue regeneration and stem cell regulation. Commercial MSX1 antibodies are typically raised in rabbits or mice, targeting specific epitopes of the protein. Validation includes knockout controls and cross-reactivity checks to ensure specificity. Overall, MSX1 antibodies remain vital for unraveling developmental mechanisms and disease pathways linked to this versatile transcription factor.
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